Phase 1 Study of AWT020 in Advanced Cancer

Inclusion Criteria:

• Subject has provided informed consent prior to initiation of any study specificactivities or procedures.

• Subject must be ≥ 18 years of age or per local regulation.

• Subjects must have a histological diagnosis of solid tumors (carcinoma or sarcoma)or malignant lymphoma, either progressive locally advanced not amenable to localtherapy or metastatic, which is refractory, ineligible (in the opinion of theInvestigator) or intolerant to standard therapy. Subjects with hepatocellularcarcinoma must be diagnosed with dynamic CT or MRI if no tissue diagnosis isavailable.

• Subject must have performance status of 0, or 1 on the ECOG performance scale.

• Subject with adequate organ function.

• Life expectancy is longer than three months.

• Subject must be able to receive effective contraceptive measures.

Exclusion Criteria:

• Subject is allergic or intolerant to either anti-PD1 or interleukin-2 therapy.

• Subject has received prior immune-check point inhibitors and was discontinued due togreater than grade 3 toxicities.

• Subject is receiving other investigational agent or device.

• Subject has active infection, uncontrolled hypertension, unstable angina,uncontrolled diabetes mellitus, recent myocardial infarction, and congestive heartfailure with ejection fraction less than 50%.

• Subject has prior allogeneic stem cell or bone marrow transplant or organtransplant.

• Subject has active central nervous system (CNS) metastases or carcinomatousmeningitis.

• Subject with HIV whose viral load is > 400 copies/mL or CD4+ T cell counts are < 350cells/µL.

• Subject has baseline corrected QT interval (QTc) longer than 480 ms by Fridericiaformula.

• Subject is pregnant or breast-feeding.

• Subject has received live virus vaccine within 28 days prior to the first dose ofstudy.

• Any other conditions that might compromise the safety of the subject or theintegrity of the study.