SASL Swiss Cirrhosis Cohort

Last updated: June 24, 2024
Sponsor: University Hospital, Basel, Switzerland
Overall Status: Active - Recruiting

Phase

N/A

Condition

Scar Tissue

Hepatic Fibrosis

Hyponatremia

Treatment

Data collection

Clinical Study ID

NCT06092385
2022-01370; bb23Bernsmeier
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This is a national prospective long-term multicentre observational cohort study following patients with cirrhosis in order to systematically and longitudinally record epidemiological, clinical, histological, psychosocial and patient-reported data and biobank biological material from patients with cirrhosis.

The central element of all scientific operation and productivity in the Swiss Cirrhosis Cohort Study (SSCiCoS) is the so-called "nested project" (NP). Based on the evolving large pool of data and biological samples, SSCiCoS investigators use the data pool in order to investigate specific hypotheses and questions.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • A) Patients with chronic liver disease and histologically proven cirrhosis

  • B) Control subjects with no signs of cirrhosis

Exclusion

Exclusion Criteria:

  • Age <18 years

  • patients who developed hepatocellular carcinoma (HCC) and/or cholangiocellularcarcinoma (CCC)

Study Design

Total Participants: 3000
Treatment Group(s): 1
Primary Treatment: Data collection
Phase:
Study Start date:
June 04, 2024
Estimated Completion Date:
January 31, 2033

Study Description

For patients with end-stage cirrhosis there are no treatment options other than transplantation, a medically and ethically challenging procedure. The challenge therefore is to prevent the need for liver transplantation in as many patients with cirrhosis as possible.

In order to reach this aim, patients with cirrhosis should be identified and followed regularly according to the highest standard of current knowledge. Numerous aspects of the disease need to be detailed: its epidemiology in Switzerland, its pathophysiology including the mechanism of scar tissue generation and resolution, the associated immune dysfunction and subsequent organ failures, disease related psychosocial and behavioural factors, perceived burden of liver cirrhosis in patients, diagnostic and prognostic biomarkers for disease dynamics, both progression and regression of disease, and stage-specific therapeutic strategies.

This is a national prospective long-term multicentre observational cohort study following patients with cirrhosis in order to systematically and longitudinally record epidemiological, clinical, histological, psychosocial and patient-reported data and biobank biological material from patients with cirrhosis.

Connect with a study center

  • Arud Centre for addiction medicine Zurich

    Zurich,
    Switzerland

    Site Not Available

    12.98 miles

  • Gastroenterology and Hepatology, University Hospital Zurich

    Zurich,
    Switzerland

    Site Not Available

    12.98 miles

  • Digestive Diseases Insti- tute GastroZentrum, Hirslanden Clinic Zurich

    Zurich,
    Switzerland

    Site Not Available

    12.98 miles

  • University Centre for Gastrointestinal and Liver Diseases, University Hospital Basel, Switzerland

    Basel, 4031
    Switzerland

    Active - Recruiting

    33.85 miles

  • University Centre for Gastrointestinal and Liver Diseases, University Hospital asel, Switzerland

    Basel, 4031
    Switzerland

    Active - Recruiting

    33.85 miles

  • Department of Visceral Surgery and Medicine, University Hospital of Berne

    Bern,
    Switzerland

    Site Not Available

    54.31 miles

  • Gastroenterology and Hepatology, Lausanne University Hospital

    Lausanne,
    Switzerland

    Active - Recruiting

    102.8 miles

  • Ticino Liver Centre

    Lugano,
    Switzerland

    Site Not Available

    106.06 miles

  • Gastroenterology and Hepatology, Cantonal Hospital Ticino

    Lugano, Ticino
    Switzerland

    Active - Recruiting

    106.06 miles

  • Gastroenterology and Hepatology, University Hospital Geneva

    Geneva,
    Switzerland

    Site Not Available

    134.73 miles

  • Gastroenterology and Hepatology, Cantonal Hospital St. Gallen

    Saint Gallen,
    Switzerland

    Site Not Available

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