A Study of Apremilast in Pediatric Participants in Children With Mild to Moderate Plaque Psoriasis

Inclusion Criteria:

• Participants must have a weight of ≥ 20 kg.

• Participant must have an age and sex specific BMI value no lower in range than thefifth percentile on the growth chart for children and adolescents.

• Participant is able to swallow the study medication tablet.

• Diagnosis of chronic plaque psoriasis for at least 6 months prior to screening.

• Has mild to moderate plaque psoriasis at screening and Study Visit 1 as defined by:

• Psoriasis Area Severity Index score 2-15,

• Body surface area 2-15%, and

• Static Physician Global Assessment score of 2-3 (mild to moderate)

• Disease inadequately controlled by or inappropriate for topical therapy forpsoriasis.

Exclusion Criteria:

• Guttate, erythrodermic, or pustular psoriasis at screening and Study Day 1.

• Psoriasis flare or rebound within 4 weeks prior to screening.

• Active tuberculosis (TB) or a history of incompletely treated TB per localguidelines.

• History of recurrent significant infections.

• Active infection or infection treated with antibiotic treatment within 14 days ofStudy Day 1.

• Any history of or active malignancy or myeloproliferative or lymphoproliferativedisease.

• Current use of the following therapies that may have a possible effect on psoriasis:

• Conventional systemic therapy for psoriasis within 28 days prior to Study Day 1 (including but not limited to cyclosporine, corticosteroids, methotrexate, oralretinoids, mycophenolate, thioguanine, hydroxyurea, sirolimus, sulfasalazine,azathioprine, and fumaric acid esters).

• Phototherapy treatment (ie, ultraviolet B [UVB], PUVA) within 28 days prior to StudyDay 1.

• Biologic therapy:

• Etanercept (or biosimilar) treatment 28 days prior to Study Day 1

• Adalimumab (or biosimilar) treatment 10 weeks prior to Study Day 1

• Other TNF or IL-17 blockers (such as infliximab, certolizumab pegol,secukinumab, ixekizumab, brodalumab, or their biosimilars) within 12 weeksprior to Study Day 1

• Anti-IL-12 or anti-IL-23 treatment (such as ustekinumab, guselkumab, ortildrakizumab) within 24 weeks prior to Study Day 1.

• Use of tanning booths or other ultraviolet light sources.

• Answer "Yes" to any question on the Columbia-Suicide Severity Rating Scale duringscreening or at Study Day 1.

• Female participant of childbearing potential with a positive pregnancy test assessedat screening and/or Study Day 1 by a serum and/or urine pregnancy test.