Study of VOY-101 in Patients With Advanced Non-Neovascular Age-Related Macular Degeneration

Last updated: November 6, 2024
Sponsor: Perceive Biotherapeutics, Inc.
Overall Status: Active - Recruiting

Phase

1/2

Condition

Macular Degeneration

Aging

Geographic Atrophy

Treatment

VOY-101

Clinical Study ID

NCT06087458
PBI-AMD-002
  • Ages > 50
  • All Genders

Study Summary

The Phase 1 safety study of VOY-101 comprises of escalating dose Cohorts, followed by a Phase 2a.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Are ≥50 years of age at the time of consent.

  • Are willing and able to understand and provide written informed consent.

  • Are willing and able to return for scheduled treatment and follow-up examinations.

  • Are able to undergo ETDRS BCDVA testing and ophthalmic imaging.

  • Well-demarcated GA secondary to AMD in the absence of MNV and in the absence ofhistory of MNV.

  • Absence of signs of non-exudative MNV.

  • Additional Ocular Inclusion Criteria for study eye.

  • Meet certain genotype criteria for risk of AMD.

Exclusion

Exclusion Criteria:

  • Are women of childbearing potential (WOCBP) and are pregnant or unwilling to use anddocument use of effective contraception for the duration of the study.

  • Additional Systemic, Ocular, and Genetic Exclusion Criteria.

Study Design

Total Participants: 140
Treatment Group(s): 1
Primary Treatment: VOY-101
Phase: 1/2
Study Start date:
June 21, 2023
Estimated Completion Date:
October 31, 2027

Study Description

This is a prospective, open-label, multi-center Phase 1/2a study to evaluate the safety of a single, unilateral intravitreal (IVT) injection of escalating dose levels of VOY-101 therapy in subjects with advanced non-neovascular age-related macular degeneration (AMD).

Connect with a study center

  • Sydney Retina Clinic and Day Surgery

    Sydney, New South Wales 2000
    Australia

    Active - Recruiting

  • Cerulea Clinical Trials

    East Melbourne, Victoria 3002
    Australia

    Active - Recruiting

  • Cabrini Research

    Melbourne, Victoria 3144
    Australia

    Active - Recruiting

  • Centre for Eye Research Australia (CERA)

    Melbourne, Victoria 3002
    Australia

    Site Not Available

  • Rambam Medical Center

    Haifa,
    Israel

    Active - Recruiting

  • Tel-Aviv Sourasky Medical Center, Ophthalmology Division

    Tel Aviv, 64239
    Israel

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.