Perineural Dexamethasone in Supraclavicular Brachial Plexus Block for Anesthesia After Pediatric Hand/Wrist Surgery

Last updated: January 22, 2024
Sponsor: Poznan University of Medical Sciences
Overall Status: Active - Recruiting

Phase

4

Condition

N/A

Treatment

0.05mg/kg Dexamethasone

0.1mg/kg Dexamethasone

Placebo

Clinical Study ID

NCT06086392
12/2023
  • Ages 3-18
  • All Genders

Study Summary

Effect of Perineural Dexamethasone on the Duration of Supraclavicular Brachial Plexus Block for Anesthesia After Pediatric Hand/Wrist Surgery

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • children scheduled for hand/wrist surgery
  • body weight > 5kg

Exclusion

Exclusion Criteria:

  • infection at the site of the regional blockade
  • coagulation disorders
  • immunodeficiency
  • ASA= or >4
  • steroid medication in regular use

Study Design

Total Participants: 90
Treatment Group(s): 3
Primary Treatment: 0.05mg/kg Dexamethasone
Phase: 4
Study Start date:
October 17, 2023
Estimated Completion Date:
December 01, 2024

Study Description

This study is proposed to explore the effect of perineurial Dexamethasone on the duration of supraclavicular brachial plexus block for analgesia after pediatric ankle surgery.

After hand and wrist surgery, children need good analgesia. Peripheral nerve blocks have provided a safe, effective method to control early postoperative pain when symptoms are most severe.

The safety of local anesthesia is essential in children due to the much lower toxicity threshold of local anesthetics. An effective adjuvant, such as Dexamethasone, could allow for a higher dilution of local anesthetics while maintaining and enhancing their analgesic effect.

There is considerable research where intravenous and perineural dexamethasone use has been compared in adults. However, there is a massive lack of research regarding children.

In this study, investigators compare different doses of perineural Dexamethasone. Groups 2 and 3 have dexamethasone doses of 0.1mg/kg and 0.05mg/kg added to local anesthetic.

The investigator's goal is to find a dexamethasone dose that is as low as possible but simultaneously covers the need for good pain relief and fast recovery postoperatively.

Connect with a study center

  • Poznan University of Medical Sciences

    Poznan, Poznań 61-701
    Poland

    Active - Recruiting

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