SeeMe: An Automated Tool to Detect Early Recovery After Brain Injury

Last updated: October 10, 2023
Sponsor: Stony Brook University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Memory Loss

Traumatic Brain Injury

Neurologic Disorders

Treatment

SeeMe

Coma Recovery Scale-Revised (CRS-R)

Clinical Study ID

NCT06083441
IRB2019-00199
  • Ages 18-85
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Early prediction of outcomes after acute brain injury (ABI) remains a major unsolved problem. Presently, physicians make predictions using clinical examination, traditional scoring systems, and statistical models. In this study, we will use a novel technique, "SeeMe," to objectively assess the level of consciousness in patients suffering from comas following ABI. SeeMe is a program that quantifies total facial motion over time and compares the response after a spoken command (i.e. "open your eyes") to a pre-stimulus baseline.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18 years old or older
  • Healthy Volunteers
  • Comatose patients (patients with a GCS < 9) due to an acute brain injury (traumaticbrain injury, spontaneous subarachnoid hemorrhage, severe meningoencephalitis, etc.)

Exclusion

Exclusion Criteria:

  • A history of a neurologically debilitating disease (i.e., dementia, glioblastoma,Alzheimer's, multiple sclerosis, major vessel stroke, previous severe TBI, etc.)
  • Any other medical condition that, in the judgment of the investigator, makesparticipation in the study unsafe.
  • Pregnant subjects
  • Comatose patients without a legal authorized representative (LAR)
  • Prisoners or wards of the state
  • Persons who have not attained the legal age for consent to treatments or procedures

Study Design

Total Participants: 200
Treatment Group(s): 2
Primary Treatment: SeeMe
Phase:
Study Start date:
June 16, 2019
Estimated Completion Date:
August 31, 2025

Study Description

Acute brain injury (ABI) recovers at a variable rate. While some progress has been made in predicting long-term outcomes in traumatic brain injury (TBI) and intracranial hemorrhage, there is a critical need for short-term prediction of outcomes, in the first days and weeks after injury. With advances in machine learning and artificial intelligence, there is a growing interest in facial analysis and its application in neurological and psychiatric disorders. Here we describe "SeeMe," a novel automated objective measure of consciousness based on microexpression analyses in response to auditory commands. In measuring the smallest muscular movements undetectable by clinical observation, this technique has the high spatial resolution needed to detect hidden signs of recovery and the high temporal resolution needed to study neural circuits.

Connect with a study center

  • Stony Brook University Hospital

    Stony Brook, New York 11794
    United States

    Active - Recruiting

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