Phase
Condition
Hormone Deficiencies
Diabetes Prevention
Diabetes (Pediatric)
Treatment
N/AClinical Study ID
Ages > 18 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Eligibility criteria for individuals with pathogenic mtDNA mutations
Inclusion criteria:
Known m.3243A>G mutation in the MT-TL1 gene encoding the mitochondrial leucyl-tRNA 1gene
Other known mtDNA point mutations
Exclusion
Exclusion criteria:
Use of antiarrhythmic medications or other medications which, in the opinion of theinvestigators, have the potential to affect outcome measures.
Diagnosed severe heart disease, dysregulated thyroid gland conditions, or otherdysregulated endocrinopathies, or other conditions which, in the opinion of theinvestigators, have the potential to affect outcome measures.
Pregnancy
Eligibility criteria for controls
Exclusion criteria:
Current and regular use of antidiabetic medications or other medications which, inthe opinion of the investigators, have the potential to affect outcome measures.
Diagnosed heart disease, symptomatic asthma, liver cirrhosis or -failure, chronickidney disease, dysregulated thyroid gland conditions or other dysregulatedendocrinopathies, or other conditions which, in the opinion of the investigators,have the potential to affect outcome measures
Daily use of tobacco products
Excessive alcohol consumption
Pregnancy
Study Design
Study Description
Connect with a study center
Rigshospitalet
Copenhagen, 2100
DenmarkActive - Recruiting
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