Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of EP262 in Subjects With Chronic Spontaneous Urticaria

Last updated: March 25, 2025
Sponsor: Escient Pharmaceuticals, Inc
Overall Status: Terminated

Phase

2

Condition

Urticaria

Hives (Urticaria)

Treatment

Placebo

Oral EP262

Clinical Study ID

NCT06077773
EP-262-201
  • Ages 18-80
  • All Genders

Study Summary

Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of EP262 in Subjects with Chronic Spontaneous Urticaria

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Documented history of chronic spontaneous urticaria (CSU) with a UAS7 greater thanor equal to 16 despite stable treatment with H1 antihistamine consistent withstandard of care

  • Must be on a stable dose of H1 antihistamine up to 4 times the approved dose perlocal treatment guidelines

Exclusion

Exclusion Criteria:

  • Urticaria with a clear underlying etiology other than CSU

  • Urticaria with a clearly defined or sole trigger (chronic inducible urticaria)

  • Other active skin diseases associated with chronic pruritus (eg, atopic dermatitis,bullous pemphigoid, prurigo nodularis, dermatitis herpetiformis)

Study Design

Total Participants: 113
Treatment Group(s): 2
Primary Treatment: Placebo
Phase: 2
Study Start date:
September 25, 2023
Estimated Completion Date:
January 16, 2025

Connect with a study center

  • Red Maple Trials Inc.

    Ottawa, Ontario K1H1E4
    Canada

    Site Not Available

  • Evidence Based Medical Educator Inc

    Toronto, Ontario M5G 1E2
    Canada

    Site Not Available

  • Centre de Recherche Saint-Louis

    Québec, Quebec
    Canada

    Site Not Available

  • Gordon Sussman Clinical Research

    North York, M3B 3S6
    Canada

    Site Not Available

  • Medizinische Hochschule Hannover

    Hannover, Niedersachsen 30625
    Germany

    Site Not Available

  • Universitatsmedizin Mainz der Johannes Gutenberg-Universitat

    Mainz, Rheinland-Pfalz 55131
    Germany

    Site Not Available

  • Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden

    Dresden, Sachsen 01307
    Germany

    Site Not Available

  • Institut fur Allergieforschung Charite - Universitatsmedizin Berlin

    Berlin, 12203
    Germany

    Site Not Available

  • Centre for Human Drug Research

    Leiden, South Holland 2333 CL
    Netherlands

    Site Not Available

  • Pim Mswia

    Warsaw, Masovian Voivodeship 02-507
    Poland

    Site Not Available

  • Prywatna Praktyka Lekarska Ewa Ring

    Warszawa, Mazowieckie 02-482
    Poland

    Site Not Available

  • Centrum Badan Klinicznych PI-House Sp. z o.o.

    Gdańsk, Pomorskie 80-546
    Poland

    Site Not Available

  • Hospital del Mar

    Barcelona, 08003
    Spain

    Site Not Available

  • Hospital Clinico San Carlos

    Madrid, 28040
    Spain

    Site Not Available

  • Hospital Arnau de Vilanova

    Valencia, 46015
    Spain

    Site Not Available

  • AllerVie Clinical Research

    Birmingham, Alabama 35209
    United States

    Site Not Available

  • Scottsdale Clinical Trials

    Scottsdale, Arizona 85260
    United States

    Site Not Available

  • Little Rock Allergy & Asthma Clinical Research Center

    Little Rock, Arkansas 72205
    United States

    Site Not Available

  • First OC Dermatology Research, Inc.

    Fountain Valley, California 92708
    United States

    Site Not Available

  • Allergy and Asthma Specialists Medical Group

    Huntington Beach, California 92647
    United States

    Site Not Available

  • Antelope Valley Clinical Trials

    Los Angeles, California 90025
    United States

    Site Not Available

  • Allervie Clinical Research

    Destin, Florida 32541
    United States

    Site Not Available

  • Florida Center for Allergy and Asthma Research

    Miami, Florida 33186
    United States

    Site Not Available

  • University of Miami Itch Center

    Miami, Florida 33136
    United States

    Site Not Available

  • NuLine Clinical Trial Center

    Pompano Beach, Florida 33060
    United States

    Site Not Available

  • Advanced Clinical Research Institute

    Tampa, Florida 33607
    United States

    Site Not Available

  • University of South Florida

    Tampa, Florida 33612
    United States

    Site Not Available

  • Treasure Valley Medical Research

    Boise, Idaho 83706
    United States

    Site Not Available

  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana 46250
    United States

    Site Not Available

  • Southern Indiana Clinical Trials

    New Albany, Indiana 47150
    United States

    Site Not Available

  • The Indiana Clinical Trials Center

    Plainfield, Indiana 46168
    United States

    Site Not Available

  • Velocity Clinical Research, Overland Park, KC Asthma & Allergy

    Overland Park, Kansas 66210
    United States

    Site Not Available

  • Allergy & Asthma Specialists, P.S.C.

    Owensboro, Kentucky 42301
    United States

    Site Not Available

  • Johns Hopkins University

    Baltimore, Maryland 21224
    United States

    Site Not Available

  • Chesapeake Clinical Research, Inc.

    White Marsh, Maryland 21162
    United States

    Site Not Available

  • The Clinical Research Center LLC

    Saint Louis, Missouri 63141
    United States

    Site Not Available

  • Montana Medical Research, Inc.

    Missoula, Montana 59808
    United States

    Site Not Available

  • Las Vegas Clinical Trials

    North Las Vegas, Nevada 89030
    United States

    Site Not Available

  • Corning Center for Clinical Research

    Horseheads, New York 14845
    United States

    Site Not Available

  • Bobby Buka MD, PC

    New York, New York 11211
    United States

    Site Not Available

  • Allergy Partners Clinical Research

    Asheville, North Carolina 28803
    United States

    Site Not Available

  • Bernstein Clinical Research Center, LLC

    Cincinnati, Ohio 45236
    United States

    Site Not Available

  • Toledo Institute of Clinical Research Inc.

    Toledo, Ohio 43617
    United States

    Site Not Available

  • Vital Prospects Clinical Research Institute, PC

    Tulsa, Oklahoma 74136
    United States

    Site Not Available

  • Allergy and Clinical Immunology Associates

    Pittsburgh, Pennsylvania 15241
    United States

    Site Not Available

  • Clinical Partners, LLC

    Johnston, Rhode Island 02919
    United States

    Site Not Available

  • National Allergy and Asthma Research, LLC.

    North Charleston, South Carolina 29420
    United States

    Site Not Available

  • Progressive Clinical Research, PA

    San Antonio, Texas 78213
    United States

    Site Not Available

  • Allergy Associates of Utah

    Murray, Utah 84107
    United States

    Site Not Available

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