A Combined Biomarker Model for Risk Stratification of Indeterminate Pulmonary Nodules

Inclusion Criteria:

• Adults > 21 y/o

• IPNs 8-30mm referred for evaluation Figure 4. AUC and reclassification of CombinedBiomarker Model

• Intermediate risk IPN defined as 10-70% risk after applying Mayo risk predictormodel

• Solid nodules or part-solid nodules with solid component >=8mm

• CT scan with nodule of concern performed within 60 days of enrollment

Exclusion Criteria:

Pure ground glass nodule or subsolid nodule with solid component <8mm

• Currently on therapy for any cancer

• History of primary lung cancer within the last 5 years

• Multiple nodules highly suspicious for metastatic disease

• Other malignancy within the last 2 year - Excluding skin cancer other than melanoma

• Pregnant women

• Prisoners

• Inability to provide informed consent

• Serologic evidence of active fungal infection