Adolescent Mood During Puberty and Testosterone

Last updated: October 16, 2024
Sponsor: University of North Carolina, Chapel Hill
Overall Status: Active - Recruiting

Phase

N/A

Condition

Depression

Treatment

Healthy Minds Program

Clinical Study ID

NCT06072677
23-1336
  • Ages 11-14
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention deficit hyperactivity disorder (ADHD). This divergence between the sexes during puberty suggests sex-specific pathways of risk and differential effects of sex hormones. The purpose of this research is to determine: 1) sex-specific neural and endocrine features of the pubertal transition that may mediate sex differences in adolescent mood disorders, and 2) the neurophysiological basis of susceptibility to hormone change during puberty.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Between the ages of 11 and 14

  • Have their own personal mobile device and capability to download the MyCap andHealthy Minds apps

  • Experienced a stressful life event within the last year, or endorse moderatedepression (defined by a CES-DC score 16 or higher)

Exclusion

Exclusion Criteria:

  • Previous experience with the Healthy Minds Program

  • Regular meditation practice

  • Current or history of manic episodes, psychotic symptoms, or current suicidal intent

  • Taking any form of exogenous hormones or intrauterine device (IUD) within one monthof participation in the study

  • Taking medications that directly alter cardiovascular or neurological function

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: Healthy Minds Program
Phase:
Study Start date:
August 24, 2023
Estimated Completion Date:
December 31, 2027

Connect with a study center

  • Carolina Crossing B, Suite 1

    Chapel Hill, North Carolina 27517
    United States

    Active - Recruiting

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