A Study to Assess Prevalence of a Specific Protein Overexpression in Adult Participants With Non-Small Cell Lung Cancer

Last updated: January 27, 2025
Sponsor: AbbVie
Overall Status: Completed

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06068842
H24-281
  • Ages > 18
  • All Genders

Study Summary

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 80%-85% of lung cancers cases of which 60% are non-squamous (NSQ). This study will evaluate the prevalence of mesenchymal epithelial transition (MET) overexpression (OE) in adult participants with advanced or metastatic NSQ NSCLC.

Archived tissue biopsies will be tested for MET OE and data from approximately 500 participants will be collected. No participants will be enrolled in this study.

Participants' charts will be reviewed. No drug will be administered as a part of this study. The duration of the study will be approximately 15 months.

There is no additional burden for participants in this trial.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Previously consented and/or prospective collection of consent for research use ofbanked biological materials and clinical data.

  • Confirmed advanced and/or metastatic non-squamous (NSQ) non-small cell lung cancer (NSCLC).

  • Has formalin-fixed paraffin-embedded (FFPE) tissue collected since 2019.

Exclusion

Exclusion Criteria:

  • Specimens collected before 2019.

  • Insufficient specimen tissue for testing.

  • Insufficient specimen quality (e.g., not 4-5 µm in thickness) which precludestesting.

  • Adenosquamous and sarcomatous histologies of NSCLC.

Study Design

Total Participants: 579
Study Start date:
November 03, 2023
Estimated Completion Date:
December 31, 2024

Connect with a study center

  • Hospital Italiano de Buenos Aires /ID# 256999

    Ciudad Autonoma Buenos Aires, Ciudad Autonoma De Buenos Aires 1199
    Argentina

    Site Not Available

  • Instituto Alexander Fleming /ID# 256295

    Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires 1426
    Argentina

    Site Not Available

  • Irmandade da Santa Casa de Misericordia de Porto Alegre /ID# 256487

    Porto Alegre, Rio Grande Do Sul 90020-090
    Brazil

    Site Not Available

  • Hospital Alemao Oswaldo Cruz /ID# 256486

    Sao Paulo, 01323-020
    Brazil

    Site Not Available

  • Nova Scotia Health Authority /ID# 256950

    Halifax, Nova Scotia B3H 1V8
    Canada

    Site Not Available

  • Institut universitaire de cardiologie et de pneumologie de Québec - Université L /ID# 257872

    Québec, Quebec G1V 4G5
    Canada

    Site Not Available

  • Royal University Hospital /ID# 261272

    Saskatoon, Saskatchewan S7N 0W8
    Canada

    Site Not Available

  • West China Hospital, Sichuan University /ID# 256906

    Chengdu, Sichuan 610041
    China

    Site Not Available

  • Rambam Health Care Campus /ID# 256546

    Haifa, H_efa 3109601
    Israel

    Site Not Available

  • Kindai University Hospital /ID# 257890

    Osakasayama-shi, Osaka 589-8511
    Japan

    Site Not Available

  • National Cancer Center Hospital /ID# 257889

    Chuo-ku, Tokyo 104-0045
    Japan

    Site Not Available

  • The Catholic University of Korea, Yeouido ST. Mary's Hospital /ID# 261511

    Seoul, Seoul Teugbyeolsi 07345
    Korea, Republic of

    Site Not Available

  • UOMi Cancer Center - Clinica Tres Torres /ID# 261212

    Barcelona, 08017
    Spain

    Site Not Available

  • Universitätsspital Basel /ID# 256677

    Basel Town, Basel-Stadt 4031
    Switzerland

    Site Not Available

  • University Hospital Zurich /ID# 256678

    Zurich, Zuerich 8006
    Switzerland

    Site Not Available

  • National Taiwan University Hospital /ID# 261542

    Taipei City, Taipei 100
    Taiwan

    Site Not Available

  • Burjeel Medical City /ID# 259407

    Abu Dhabi, 0
    United Arab Emirates

    Site Not Available

  • Queen's University Belfast /ID# 258458

    Belfast, Northern Ireland BT9 7AE
    United Kingdom

    Site Not Available

  • University Hospitals Birmingham NHS Foundation Trust /ID# 260991

    Birmingham, B15 2TH
    United Kingdom

    Site Not Available

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