Venetoclax Plus CACAG Regimen for Newly Diagnosed Acute Myeloid Leukemia

Inclusion Criteria:

Patients who are able to understand and willing to sign the informed consent form (ICF).

• All patients should aged 14 to75 years,no gender limitation.

• Patients who are newly diagnosed with AML(no M3).

• Liver function: ALT and AST≤2.5 times the upper limit of normal ,bilirubin≤2 timesthe upper limit of normal;

• Renal function: creatinine ≤the upper limit of normal;

• Patients without any uncontrolled infections , without organ dysfunction or withoutsevere mental illness;

• The score of Eastern Cooperative Oncology Group (ECOG) is 0-2, and the predictedsurvival ≥ 4 months.

• Patients without severe allergic constitution.

Exclusion Criteria:

• Patients with allergy or contraindication to the study drug;

• Female patients who are pregnant or breast-feeding.

• Patients with a known history of alcohol or drug addiction on the basis that therecould be a higher risk of non-compliance to study treatment;

• Patients with mental illness or other states unable to comply with the protocol;

• Less than 6 weeks after surgical operation of important organs.

• Liver function: ALT and AST>2.5 times the upper limit of normal ,bilirubin> 2 timesthe upper limit of normal;Renal function: creatinine >the upper limit of normal;

• The patient is not suitable for this clinical trial (poor compliance, substanceabuse, etc.)