Selective Reporting for Antibiotic Susceptibility Testing and GPs' Prescribing of Broad-spectrum Antibiotics in Women With E. Coli UTIs

Phase

N/A

Condition

Urinary Tract Infections

Treatment

Dissemination of a selective reporting for antibiotic susceptibility testing

Standard antibiotic susceptibility testing report

Clinical Study ID

NCT06067386

RC22_0003

Ages > 18
Female

Study Summary

The control of antibiotic resistance requires a reduction in inappropriate prescriptions of broad-spectrum antibiotics (amoxillin-clavulanate (AMC), fluoroquinolones (FQ), third-generation cephalosporins (C3G)), particularly for urinary tract infections treated in primary care. Several studies have reported the positive impact of antibiotic susceptibility testing performed on urine cultures on the appropriate use of antibiotics.

The "selective reporting for antibiotic susceptibility testing ", defined as the restriction of the list of antibiotics mentioned in the report according to the antibiotic resistance profile, would allow, according to observational studies, a reduction of 25 to 70% of the initial prescriptions of broad-spectrum antibiotics and a 20% rate of antibiotic de-escalation (=reduction of the antibacterial spectrum of an antibiotic treatment after re-evaluation).

The objective is to assess the impact of disseminating a selective reporting for antibiotic susceptibility testing on the dispensing of broad-spectrum antibiotics prescribed by general practitioners (GPs) for E. coli positive urine cultures in adult women, compared to the dissemination of a standard antibiotic susceptibility testing.

Eligibility Criteria

Inclusion

Inclusion Criteria: Patients :

women ≥18 years of age,
affiliated with the CPAM of Loire Atlantique (44) or Maine et Loire (49),
with a urine culture: i) analyzed by LabOuest, ii) positive for E. coli, and iii)associated with a prescription for antibiotics by a general practitioner in the period 7 days before and 14 days after the antibiotic susceptibility testing. General practitioners :
practicing in primary care Loire Atlantique (44) and/or Maine et Loire (49),
having been consulted by at least 100 different patients in the 12 months prior tobaseline,
having received at least one urine culture result for a woman ≥18 years of ageanalyzed by LabOuest over the 12 months prior to baseline.

Exclusion

Exclusion Criteria: Patients :

hospitalized in the period 7 days before and 14 days after antibiotic susceptibilitytesting (data on antibiotics dispensed in healthcare institutions are not accessiblevia DCIR data),
with reimbursements for antibiotics prescribed by physicians in different practicesover the period 7 days before and 14 days after antibiotic susceptibility testing. General practitioners :
with a special practice (acupuncture, allergology, angiology).
not receiving any urine culture results analyzed by a laboratory of the LabOuestnetwork in the year following the intervention

Study Design

Dissemination of a selective reporting for antibiotic susceptibility testing

November 21, 2023

November 21, 2024

Connect with a study center

University Hospital
Nantes, 44000
France
Active - Recruiting

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