Propranolol in Primary Progressive Aphasia

Last updated: March 24, 2025
Sponsor: University of Missouri-Columbia
Overall Status: Active - Recruiting

Phase

1

Condition

Memory Loss

Speech Disorders

Communication Disorders

Treatment

Propranolol

Placebo

Magnetic Resonance Imaging (MRI)

Clinical Study ID

NCT06066710
2097152
  • Ages > 50
  • All Genders

Study Summary

The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure.

This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age: 50 and older
  1. Primary Progressive Aphasia diagnosis
  1. Native English speaker

Exclusion

Exclusion Criteria:

  1. Unable to provide consent
  1. Taking alpha 2 agonists (clonidine and guanfacine)
  1. Other major psychological or neurological diagnosis
  1. Major head trauma that contributed to their condition
  1. Allergic reaction to adhesives
  1. Uncorrected vision/hearing impairments
  1. Diabetes
  1. Reactive airway disease
  1. Untreated hypothyroidism
  1. Bradyarrhythmia
  1. Unexplained syncope
  1. Pregnancy (assessed verbally on the days of MR imaging)
  1. Drugs that interact with propranolol, such as alpha 2 agonists
  1. Claustrophobia, inner ear implants, aneurysm or other surgical clips, metalforeign bodies in eye, pacemaker or other contraindication to MR scanning.Subjects with any implanted device that cannot be verified as MRI compliantwill be excluded.

Study Design

Total Participants: 30
Treatment Group(s): 3
Primary Treatment: Propranolol
Phase: 1
Study Start date:
January 13, 2025
Estimated Completion Date:
December 31, 2027

Connect with a study center

  • University of Missouri-Columbia

    Columbia, Missouri 65212
    United States

    Active - Recruiting

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