Low-Frequency REpetitive TRanscranial Magnetic Stimulation in ACute Ischemic StrokE Within 48 Hours

Inclusion Criteria:

1. Age 18-80 years, gender is not limited;
2. Acute ischemic stroke of anterior circulation was diagnosed clinically
3. mRS 0-1 score before onset;
4. 6 ≤ NIHSS ≤25 at randomization;
5. Within 48 hours of stroke onset;
6. No thrombolysis therapy or thrombectomy is planned;
7. Obtain informed consent signed by the patient himself or by his legal authorizedrepresentative.

Exclusion Criteria:

1. TMS contraindications include metallic foreign bodies in the head, pacemaker,implantable drug pumps, cochlear implants, etc.
2. Epilepsy or history of epilepsy, intracranial hypertension, tumor and other seriousneurological disorders;
3. Midline displacement and brain parenchymal mass effect seen in head CT and otherimages;
4. Head CT or MRI showed bilateral acute cerebral infarction and involved insularinfarction;
5. Evidence of acute intracranial hemorrhage;
6. A history of congenital or acquired hemorrhagic disease, coagulation factordeficiency, or thrombocytopenia disease;
7. After blood pressure control, the systolic blood pressure was still ≥180 mmHg or thediastolic blood pressure was ≥110 mmHg;
8. Known recent or current serum creatinine exceeding 1.5 times the upper limit of normalor estimated glomerular filtration rate (EGFR) < 60 mL/min;
9. Patients during pregnancy or lactation and within 90 days of planned pregnancy;
10. Patients with severe mental disorders or dementia who can not cooperate with informedconsent and follow-up;
11. Patients with malignancy or severe systemic disease and expected survival of less than 90 days;
12. Participants in other clinical intervention studies within 30 days beforerandomization or who were participating in other clinical intervention studies.