Capsule Microbiota Transplant Therapy for Hidradenitis Suppurativa

Inclusion Criteria:

• Able and willing to provide informed consent

• English speaking

• Age >= 18years of age

• Diagnosis of hidradenitis suppurativa by a dermatologist

• Women who are not post-menopausal (at least 12 months of non-therapy inducedamenorrhea) or surgically sterile (e.g. absence of ovaries and/or uterus) mustremain abstinent or use a highly effective form of birth control (e.g. oralcontraception, transdermal patch, barrier, intrauterine device). Periodic abstinenceand early withdraw are not acceptable methods

• Able to comply to study measures in the opinion of the investigator.

• Stable doses of all medications for 30 days prior to baseline

Exclusion Criteria:

• Non-English speaking

• Refusal or inability to provide informed consent

• Planning on moving within 6 months from start of study

• Allergy to neomycin or vancomycin

• Anaphylactic food allergies

• Pregnancy, breastfeeding or planning pregnancy during study period (negativepregnancy test needed for persons of childbearing potential)

• Use of any topical or oral antibiotics within 30 days of randomization

• Use of any oral antibiotics within 90 days of randomization

• History of inflammatory bowel disease

• Extensive bowel resection (e.g., subtotal colectomy, substantial removal of smallbowel)

• No major bowel surgery within 4 weeks prior to baseline or planned major surgeryduring the study period

• No active skin disease other than HS that could interfere with assessments