CRP/Albumin Ratio as a Predictive Inflammatory Marker for Postoperative SIRS and/or Sepsis

Last updated: March 28, 2025
Sponsor: Ain Shams University
Overall Status: Completed

Phase

N/A

Condition

Soft Tissue Infections

Treatment

CRP and Albumin level in blood sample

Clinical Study ID

NCT06050759
MD134/2023
  • Ages > 18
  • All Genders

Study Summary

The goal of this observational study is to determine the value of CRP/Albumin Ratio as an inflammatory marker for predicting the development of postoperative Systemic Inflammatory Response Syndrome and/or Sepsis in polytraumatized patients admitted to Intensive care unit.

The main question it aims to answer is whether CRP/Albumin Ratio can be used as predictive inflammatory marker for postoperative Systemic Inflammatory Response Syndrome and/or Sepsis or not.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients classified by American Society of Anesthesiologists physical status (ASA)as I to III.

  • Both sex.

  • Aged ≥ 18 years old.

  • Polytraumatized patients (fulfilling the 'New Berlin definition' of Polytraumapatient which includes Abbreviated Injury Scale (AIS) ≥3 for two or more differentbody regions with one or more of the following five physiological variables:Disturbed level of consciousness, hypotension, coagulopathy, acidosis and age >70y).

  • Admitted to Intensive Care Unit preoperatively or postoperatively. • Surgicalintervention within 48 hours of the onset of Trauma.

Exclusion

Exclusion Criteria:

  • Patients who used immunosuppressive therapy and chemotherapy.

  • Patients with known hematological disorders or malignancy.

  • Patients with known liver cirrhosis classified as Child- Pugh C ( serum Albumin < 2.8 mg/dl or International Normalized Ratio > 2.2 ) (Tsoris , et al.,2023) or livercell failure.

  • Patients receiving Albumin Supplementation during the period of the study.

  • Age < 18y.

Study Design

Total Participants: 100
Treatment Group(s): 1
Primary Treatment: CRP and Albumin level in blood sample
Phase:
Study Start date:
December 01, 2023
Estimated Completion Date:
December 30, 2024

Study Description

The development of postoperative Systemic Inflammatory Response Syndrome (SIRS) or Sepsis is a very serious complication that has been associated with high morbidity, mortality, and increased length of inpatient stay.

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.

As surgical interventions lead to well-understood metabolic, neuroendocrine, and immune responses, the stress responses to surgery contribute to increased postoperative complications mostly caused by increased levels of Pro-inflammatory cytokines in response to surgical injury, which leads to changes of circulating acute phase proteins, such as albumin and C-reactive protein (CRP).

The CRP to albumin ratio (CAR) is a new index calculated by dividing CRP by the albumin level. It has been assumed to have predictive value in determining morbidity and mortality in many critical diseases.

Connect with a study center

  • AinShams University Specialized Hospital

    Cairo, Abbasia
    Egypt

    Site Not Available

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