This study consists of 7 study visits that occur over 6 months after operative fixation
of femoral fragility fracture. Consenting participants will be asked to complete the
study assessments/procedures at the time points described below. Patients will be treated
with operative fixation of their fracture per standard of care.
Body composition: Will be assessed using a bioelectrical impedance analysis (BIA)
device (InBody S10 Body Composition Analyzer). This is non-invasive test that uses a
low-level imperceptible electrical current to measure body composition and body
water. In a supine position, electrodes are placed on the hands and ankles of the
subjects and the result is recorded in the BIA device. This assessment will be
performed by trained study team members.
Visual Analog Scale (VAS): This is a survey to report on subjective pain.
Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function:
This is a survey that asks subjects to report on subjective measures of pain and
physical function. This survey is a computer adaptive test that is completed in
REDCap® using a tablet or computer. Subjects will self-administer this survey
Mini Nutrition Assessment (MNA): This is a survey designed for elderly patients to
identify malnourishment or risk thereof. This survey is a computer adaptive test
that is completed in REDCap® using a tablet or computer.
Protein Screener: This is a survey designed for older adults to screen for low
protein intake. This survey is a computer adaptive test that is completed in REDCap®
using a tablet or computer.
Barthel Activities of Daily Living Index is a commonly used measure of activities of
daily living outcomes for older adults. It measures the ability to perform
activities of daily living that are important for maintaining function including
feeding, bathing, grooming, dressing, bowel control, bladder control, toilet use,
transfers from bed to chair and back, mobility on level surfaces, and stairs. Each
measure is assessed on a 10-point scale, all scores are combined to give a score out
of 100 points. The higher the score the more independent the individual.
Residence at a nursing home will be recorded at each follow up visit. Participants
living in an assisted living home (apartment or condominium with nursing assistance
on call), apartment, single family home, or family member's home are considered
living in the community.
Patients will be given an adverse event log to track any side effects or falls. We
will encourage patients to call us but would like them to have a note sheet in case
they forget.
Patients randomized to the supplement group will be given a take home supplement log
where they will track their AM and PM doses.
All patients will be given logs to keep track of their daily pain, PT and number of
meals eaten.
3 Week Clinic Visit:
Muscle biopsies
Systemic inflammatory labs
Body composition: InBody S10 Body Composition Analyzer
Visual Analog Scale (VAS)
Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function
Barthel Activities of Daily Living Index
Residence at a nursing home.
Supplement Compliance: Patients will be asked to return completed log sheets and if
they were randomized to the supplement group, being in their supplement containers
to be weighed.
6-Week Clinic Visit:
Body composition: InBody S10 Body Composition Analyzer
Visual Analog Scale (VAS)
PROMIS Physical Function
Barthel Activities of Daily Living Index
Residence at a nursing home
Supplement compliance
12-week Clinic Visit:
Body composition: InBody S10 Body Composition Analyzer
Visual Analog Scale (VAS)
PROMIS Physical Function
Mini Nutrition Assessment (MNA)
Protein Screener
Barthel Activities of Daily Living Index
Residence at a nursing home
Physical Performance Measures: Objective measures of physical performance (mobility,
strength, power, & balance) will be assessed with the Short Physical Performance
Battery (SPPB)14 and the Timed Up & Go (TUG)15 test. During the SPPB, subjects will
complete the following physical assessments - ability to stand for 10 seconds with
feet in 3 different positions (together side-by-die, semi-tandem, & tandem), two
timed trials of a 4-meter walk, and time to rise from a chair 5 times. During the
TUG, subjects will complete the following physical assessment - time to rise from a
chair, walk 3 meters, return, & sit down. This assessment will be performed by
trained study team members.
6-month Phone Call:
PROMIS Physical Function
Barthel Activities of Daily Living Index
Residence at a nursing home