Novel Amblyopia Treatment With Virtual Reality Games

Inclusion Criteria:

Patients ages 5 to 17 years of age

• Moderate to severe unilateral amblyopia (logMAR best corrected visual acuity 0.3 to 1.3) associated with anisometropia and/or strabismus of ≤5pd

• Age normal VA in the nonamblyopic eye

• Spectacle correction (if required) worn for at least 16 weeks, or until stability ofVA is demonstrated (<0.1 logMAR change by the same testing method measured on 2exams at least 8 weeks apart)

• Interocular difference of ≥ 3 lines

• No amblyopia treatment in the past 2 weeks

• An interpupillary distance of 52-72 mm (inclusive)

Exclusion Criteria:

• Myopia greater than -6.00 diopters (D) spherical equivalent in either eye.

• Previous intraocular or refractive surgery.

• Previous dichoptic treatment > 2 weeks in duration

• Ocular co-morbidity that may reduce visual acuity determined by an ocularexamination performed within the past 7 months (Note: nystagmus per se does notexclude the participant if the above visual acuity criteria are met).

• Diplopia more than once per week over the last week prior to enrollment by parentalreport.

• Down syndrome or cerebral palsy.

• Light-induced seizures

• Known simulator sickness

• Severe developmental delay that would interfere with treatment or evaluation (in theopinion of the investigator). Participants with mild speech delay or reading and/orlearning disabilities are not excluded.