Evaluation of the Efficacy of Two Dietary Supplements Claiming Anti-aging Properties

Inclusion criteria :

• Healthy female subjects,
• Caucasian ethnicity,
• Age between 30 and 60 years old (extremes included),
• Wrinkles related to chronological ageing (from mild to moderate),
• Wrinkles related to photo-ageing (medium photo-ageing signs, dry and devitalized skin,asphyxia, pale and greyish skin, early ageing signs caused by a slowing in the cellsactivity),
• Subjects with dry skin defined with corneometric index < 50 a.u.,
• Body mass index BMI between 19 and 30,
• At least 10 menopause women per group,
• Subjects who have not been recently involved in any other similar study (evaluation isperformed case by case by the experimenter but at least 1 month must be elapsedbetween a previous study on food supplement),
• Willingness not to use chemical products or treatments on hair and nails (such as haircolour, straightening, permanent nail polish) in the two weeks preceding T56 visit,
• Willingness to not use during the study period products other than the test product,
• Willingness to not vary the normal diet and daily routine (at the beginning of thestudy volunteers list their usual routine: sport activities, sleeping habits, etc. ),
• Subjects under effective contraception (oral/not oral) if women of childbearingpotential; not expected to be changed during the trial,
• Subjects who have not sun exposure (both natural or artificial) for at least twomonths
• Subjects who accept not to expose in intensive way to UV rays during the whole studyduration,
• Willingness not to use similar products that could interfere with the product to betested,
• Subject aware of the study procedures and having signed an informed consent form.

Exclusion Criteria:

• Subject does not meet the inclusion criteria,
• Subject with known or suspected sensitization to one or more test formulationingredients,
• Any condition that the principal investigator deems inappropriate for participation,
• Pregnant/breastfeeding female or who have planned a pregnancy during the study period,
• Pharmacological treatments (topic or systemic) known to interfere with skinmetabolism/physiology,
• Lipid metabolism disorders (hypercholesterolemia, hyperlipidemia) and followingtreatment for theses disease,
• Subjects under locally pharmacological treatment on the skin area monitored during thetest,
• Subjects under treatment with food supplements which could interfere with thefunctionality of the product under study,
• Subjects which show skin alterations on the monitored area which could interfere withthe functionality of the product under study,
• Subjects who underwent to botox, hyaluronic acid, collagen injections or each type offacial surgery in the past 6 months,
• Severe concurrent diseases,
• Adult protected by the law (under guardianship, or hospitalized in a public or privateinstitution, for a reason other than the research, or incarcerated),
• Subject is unable to communicate or cooperate with the Investigator due to languageproblems, poor mental development, or impaired cerebral function,
• Subjects resulting positive to Sars-Cov. 19 in the past 6 months/ during the study
• Subjects not presenting a valid Greenpass.