Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia

Inclusion Criteria:

1. Be able and willing to provide written informed consent prior to any study procedurebeing performed;

2. Be able and willing to follow all instructions and attend all study visits;

3. Be 45-75 years of age of either sex at Visit 1;

4. Have +1.00 to -4.00 diopter (D) of sphere calculated in minus cylinder in both eyesdetermined by manifest refraction documented at Visit 1;

5. Have ≤2.00 D of cylinder (minus cylinder) in both eyes determined by manifestrefraction documented at Visit 1;

6. Have +1.00 D to -4.00 D manifest refraction spherical equivalent（MRSE）of Sphericalequivalent (SE) determined by manifest refraction documented at Visit 1.

7. Be presbyopic as determined at Visit 2 baseline

Exclusion Criteria:

1. Be a female of childbearing potential who is currently pregnant, nursing, orplanning a pregnancy;

2. Have known contraindications or sensitivity to the use of any of the studymedications or their components;

3. Have an active ocular infection at Visit 1 or at Visit 2 (bacterial, viral, orfungal), positive history of an ocular herpetic infection, preauricularlymphadenopathy, or ongoing, active ocular inflammation (e.g., moderate to severeblepharitis, allergic conjunctivitis, peripheral ulcerative keratitis, scleritis,uveitis) in either eye;

4. Have moderate or severe dry eye at Visit 1, assessed by corneal fluoresceinstaining;

5. Have clinically significant abnormal lens findings (e.g., cataract) including earlylens changes and/or any evidence of a media opacity during dilated slitlampbiomicroscopy and fundus exam documented within 3 months of Visit 1 or at Visit 1;