A Community-Based Screening Program to Identify Participants at High Risk for Amyloid Pathology

Inclusion Criteria:

1. Male or female, age 50 to 80 years inclusive, at the time of informed consent

• Those 50 to 64 years of age must have 1 of the following risk factors confirmedprior to blood sample collection:

• First degree relative with dementia onset before age 75,

• Known before screening to have at least 1 Apolipoprotein E4 (APOE4) allele, or

• Known before screening to have elevated brain amyloid according to previouspositron emission tomography (PET), cerebrospinal fluid (CSF), or blood testing

2. Provide written informed consent

3. Willing and able to comply with all aspects of the protocol

4. Willing to be referred to a clinical site if the assessment results meet thecriteria

Exclusion Criteria:

1. Known uncontrolled medical conditions (example, cardiac, respiratory,gastrointestinal, psychiatric, renal disease, malignant neoplasm)

2. Participation in an interventional clinical trial study at the time of consent