Effectiveness and Safety of Platelet-rich Plasma and Topical 5% Minoxidil Combination in Male Androgenetic Alopecia

Last updated: September 12, 2023
Sponsor: Indonesia University
Overall Status: Active - Not Recruiting

Phase

4

Condition

Alopecia

Male Pattern Baldness

Hair Loss

Treatment

Platelet-Rich Plasma and Topical 5% Minoxidil

Topical 5% Minoxidil

Clinical Study ID

NCT06043349
23020292
  • Ages 18-50
  • Male
  • Accepts Healthy Volunteers

Study Summary

The goal of this clinical trial is to learn about the effectiveness and safety of platelet-rich plasma (PRP) and topical 5% minoxidil combination therapy compared with topical 5% minoxidil monotherapy in male androgenetic alopecia.

The main questions it aims to answer are:

  • Is there a difference in average change of hair density between groups that were given a combination of PRP injection and topical minoxidil compared to topical minoxidil as monotherapy?

  • Is there a difference in average change of hair thickness between groups that were given a combination of PRP and topical minoxidil compared to topical minoxidil as monotherapy?

  • Are there any differences in side effects between groups that were given combination of PRP and topical minoxidil compared to topical minoxidil as monotherapy?

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Men between 18 and 50 years old
  • Diagnosed with grade III-VI androgenetic alopecia based on Hamilton-Norwood scale
  • Willing to be the research subject and make regular follow-up visits.

Exclusion

Exclusion Criteria:

  • Conditions of baldness other than androgenetic alopecia based on anamnesis andphysical examination, namely telogen effluvium, alopecia areata, trichotillomania,syphilis secondary, systemic lupus erythematosus, alopecia due to chemotherapy,autoimmune, or malignancy.
  • Taking oral medications or vitamins that aim to increase the amount of hair in thelast 1 month.
  • Using topical medication that aims to increase the amount of hair in the last 2 weeks.
  • Suffering from active bacterial, viral, or fungal infections of the scalp.
  • Underwent cosmetic procedures for androgenetic alopecia treatment (such as PRPinjections, laser procedures, or microneedle) within the last 3 months prior to thestudy.
  • History of keloids.
  • History of blood clotting disorders.

Study Design

Total Participants: 36
Treatment Group(s): 2
Primary Treatment: Platelet-Rich Plasma and Topical 5% Minoxidil
Phase: 4
Study Start date:
June 01, 2023
Estimated Completion Date:
September 30, 2023

Study Description

The trial will be held for three months in Jakarta, Indonesia. Participants are required to undergo hair examinations every 4 weeks, for a total of 4 visits. Researchers will compare groups that were given a combination of PRP and topical minoxidil compared to topical minoxidil alone as a control group. Hair density, hair thickness, and overall side effects of treatment will be measured at each visit.

Connect with a study center

  • Dr. Cipto Mangunkusumo National General Hospital

    Jakarta Pusat, Greater Jakarta Area 10430
    Indonesia

    Site Not Available

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