A Study to Evaluate Effectiveness and Safety of Deucravacitinib in Participants With Non-Pustular Palmoplantar and Genital Psoriasis

Key Inclusion Criteria:

Inclusion Criteria for Non-Pustular Palmoplantar Psoriasis

• Men and women diagnosed with stable plaque psoriasis with involvement of thepalm(s)and/or sole(s) for at least 6 months or more. Stable psoriasis is defined asno morphology changes or significant flares of disease activity in the opinion ofthe investigator.

• Moderate-to-severe plaque psoriasis defined as s-PGA score of ≥ 3 on a 5-point scaleat both screening visit and Day 1.

• Moderate-to-severe non-pustular PP psoriasis, defined as pp-PGA score of ≥ 3 on a 5-pointscale and pp-PASI ≥ 8 at both screening visit and Day 1.

• A total maximum of 5 sterile pustules across both palms and soles limited onlyto psoriatic plaques will be allowed.

• Evidence of typical plaque psoriasis outside palms and soles at both screening visitand Day 1.

• Deemed by the investigator to be a candidate for phototherapy or systemic therapy.

• Failed to respond to, or intolerant of ≥ 1 topical therapy.

Inclusion Criteria for Genital Psoriasis

• Men and women diagnosed with stable plaque psoriasis with involvement of the genitalarea for at least 6 months or more. Stable psoriasis is defined as no morphologychanges or significant flares of disease activity in the opinion of theinvestigator.

• Moderate-to-severe plaque psoriasis defined as s-PGA score of ≥ 3 on a 5-point scaleat both screening visit and Day 1.

• Moderate-to-severe GenPs, defined as static Physician's Global Assessment ofGenitalia (s-PGA-G) score of ≥ 3 on a 6-point scale at both screening visit and Day

• Evidence of typical plaque psoriasis in a non-genital area at both screening visitand Day 1.

• Deemed by the investigator to be a candidate for phototherapy or systemic therapy.

• Failed to respond to, or intolerant of ≥ 1 topical therapy.

Key Exclusion Criteria:

Target Disease Exceptions

• Has non-plaque psoriasis (for PP pustulosis, PP pustular psoriasis, isolatedpustules on palms or soles with or without erythema outside psoriatic plaques,guttate, pustular, erythrodermic, and drug-induced psoriasis) at screening or Day 1.

Other protocol-defined inclusion/exclusion criteria apply.