A Home-Based Prehabilitation Exercise Intervention for Improving Physical Function in Patients With Bladder Cancer and Upper Tract Urothelial Cancer, Get Moving Trial

Inclusion Criteria:

• 18 years of age or older

• English-speaking

• Planned treatment with radical cystectomy or radical nephroureterectomy/ureterectomywith or without preceding systemic therapy as indicated by the patient's surgeonwith enough time to complete a minimum of 4 weeks of exercises before surgery ifenrolled in the (P)REHAB arm

• Willing and able to participate in trial activities

Exclusion Criteria:

• Cognitive/mental impairment that will preclude ability to participate in routineexercise activities. Significant cognitive or memory impairment or baseline dementiathat would preclude a patient's ability to follow instructions or reproduceexercises

• Immobility, inability/unwillingness to perform personalized exercise program.Inability to perform exercises safely from seated or standing position at home orrecent falls or high fall risk. Neurologic or orthopedic condition(s) that restrictsparticipation in unsupervised home exercises, such as prior stroke with neurologicimpairment, weight-bearing precautions, or unwillingness to participate in exercises

• Participants who have nonmuscle-invasive urothelial cancer of the bladder/uppertract anticipating undergoing organ-preserving treatments, or radiographic evidenceof metastatic disease involving other organs including brain metastases.

• Patients with predominant histology other than urothelial carcinoma of the bladderor upper tracts (e.g. metastasis from another cancer) who would not otherwise beconsidered candidates for standard definitive or consolidative surgeries (radicalcystectomy, ureterectomy, radical nephroureterectomy) with/without treatment withpreoperative/neoadjuvant systemic therapy.

• Uncontrolled or concurrent illness including, but not limited to, ongoing or activeinfection, symptomatic congestive heart failure, unstable angina pectoris, cardiacarrhythmia, or psychiatric illness/social situations that would limit compliancewith study requirements

• Pregnant women are excluded from this study

• Inability to understand or read English

• Lack of access or lack of sufficient facility to use an Android or iOS smart devicewith the minimum criteria for using ExerciseRx

• Not receiving surgery at UWMC

• Participation in a clinical trial that does not permit enrollment in the Get Movingtrial