Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

Last updated: May 5, 2026
Sponsor: University Hospital, Basel, Switzerland
Overall Status: Active - Recruiting

Phase

2

Condition

Diabetes Prevention

Hormone Deficiencies

Diabetes And Hypertension

Treatment

Placebo nasal spray

Intranasal OXT

Clinical Study ID

NCT06036004
2023-01010; kt22ChristCrain
  • Ages > 18
  • All Genders

Study Summary

This randomized, placebo-controlled, double-blind trial aims to investigate intranasal OXT as a novel therapeutical option in central diabetes insipidus (cDI) to improve psychological symptoms and socio-emotional functioning.

Optionally, patients can present for additional assessments in sub-studies:

  • fMRI sub-study at day 14 (± 2 days) (one additional visit)

  • Social-stress sub-study at day 14 (± 2 days) (one additional visit)

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients with a confirmed diagnosis of central diabetes insipidus based onaccepted criteria

  • Heightened anxiety levels (STAI - Trait subscale ≥ 39 score points) or alexithymialevels (impaired ability to identify and describe feelings; TAS-20 total ≥ 52 scorepoints)

  • Stable hormone replacement therapy for at least three months with desmopressin and,in case of additional anterior pituitary deficiencies, with the respectivesubstitution therapies.

Exclusion

Exclusion Criteria:

  • Participation in a trial with investigational drugs within 30 days

  • Active substance use disorder within the last six months

  • Consumption of alcoholic beverages >15 drinks/week

  • Current or previous psychotic disorder (e.g., schizophrenia spectrum disorder)

  • Pregnancy and breastfeeding within the last eight weeks

  • Unwilling to use a medically acceptable form of contraception throughout the studyperiod (female of childbearing potential only)

  • Prolonged QTc-time >470 ms assessed with a 12-lead electrocardiogram.

Study Design

Total Participants: 112
Treatment Group(s): 2
Primary Treatment: Placebo nasal spray
Phase: 2
Study Start date:
January 08, 2024
Estimated Completion Date:
October 31, 2026

Study Description

Arginine vasopressin (AVP) and oxytocin (OXT) are hormones released into circulation from the posterior pituitary. While AVP acts mainly in the kidneys and causes reuptake of free water, OXT is well-known for its key role in the regulation of complex social-emotional functioning including attachment and pair bonding, fear possessing, emotion recognition, and empathy.

Disruption of the hypothalamic-pituitary axis can cause AVP deficiency

  • known as central diabetes insipidus (cDI) - characterized by polyuria and polydipsia. Once diagnosed, desmopressin (an AVP receptor analogue) can be effectively used to treat diabetes insipidus. However, despite treatment with desmopressin, patients often report residual psychological symptoms, particularly heightened anxiety levels, depressed mood, impairment in social interactions, leading to an overall reduced quality of life.

Due to the anatomical proximity, local disruptions of the AVP system could also disturb the OXT system leading to an additional OXT deficiency. The additional OXT deficiency could explain (at least partially) the residual psychological deficits in patients with cDI. OXT replacement therapy to improve psychological symptoms would have great clinical implications. This randomized, placebo-controlled, double-blind trial aims to investigate intranasal OXT as a novel therapeutical option in cDI to improve psychological symptoms and socio-emotional functioning.

Optional fMRI sub-study: Participants will undergo a structural sequence to investigate grey and white matter anatomy (T1- weighted). Functional neuronal responses will be assessed through the surrogate of blood oxygenated level dependent (BOLD) signal, an indirect measure of neural activity. Three functional sequences (echo planar imaging, EPI) will investigate group differences in various aspects of brain activity: a resting state sequence and the EFMT.

Optional Social-stress sub-study: The three main components are an anticipation phase, a 5-minute interview, and a surprise mental arithmetic task. Acute stress is measured by cortisol increase.

Connect with a study center

  • Charité University Medical Center Berlin

    Berlin, 10117
    Germany

    Active - Recruiting

  • Erasmus University Medical Center Rotterdam

    Rotterdam, 3015
    Netherlands

    Active - Recruiting

  • Erasmus University Medical Center Rotterdam

    Rotterdam 2747891, 3015
    Netherlands

    Site Not Available

  • University Hospital Basel, Department of Endocrinology, Diabetes & Metabolism

    Basel, 4031
    Switzerland

    Active - Recruiting

  • University Hospital Basel, Department of Endocrinology, Diabetes & Metabolism

    Basel 2661604, 4031
    Switzerland

    Site Not Available

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