PSYCHE Cognitive Remediation & Social Recovery Study

Last updated: March 20, 2024
Sponsor: National University of Ireland, Galway, Ireland
Overall Status: Active - Recruiting

Phase

N/A

Condition

Schizophrenia And Schizoaffective Disorders (Pediatric)

Schizotypal Personality Disorder (Spd)

Treatment

CRESTR Intervention

CRESTR Control

Clinical Study ID

NCT06032182
NUIRELAND2
  • Ages 18-60
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study is a pilot feasibility study embedded in the Early Intervention in Psychosis (EIP) services in Ireland. It explores the feasibility and acceptability of a combined cognitive remediation training and social recovery therapy intervention.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged between 18 and 60 years of age
  • Within the first 5 years of a diagnosed psychotic disorder
  • Community based and clinically stable
  • Ability to give informed consent

Exclusion

Exclusion Criteria:

  • History of organic impairment
  • IQ< 70
  • History of head injury with loss of consciousness > 5-minute duration

Study Design

Total Participants: 40
Treatment Group(s): 2
Primary Treatment: CRESTR Intervention
Phase:
Study Start date:
March 01, 2023
Estimated Completion Date:
December 31, 2025

Study Description

The Cognitive Remediation and Social Recovery in Early Psychosis (CRESTR) study is a feasibility study recruiting participants from the Health Service Executive Early Intervention in Psychosis (EIP) services in Sligo, Meath and Cork and the Adult Mental Heath Service in Galway. This study explores the feasibility and acceptability of a novel, 15-week multicomponent psychosocial intervention which combines cognitive remediation training (CRT) and social recovery therapy (SRT). Primary and secondary outcome measures are described later in this registration. The intervention components include:

Component 1: The CRT programme used in this study is the Computerised Interactive Remediation of Cognition- Training for Schizophrenia (CIRCuiTS). CIRCuiTS is a web-based CRT programme which targets metacognition, specifically strategy use, in addition to massed practice of cognitive functions (attention, memory and executive functioning). Collaborative goal setting related to real-world tasks are integral to the programme with the programme tasks and exercises increasing in difficulty in response to the participant's performance and progress. This will be the primary focus of 1:1 therapy for the first 7 weeks with remote practice sessions occurring between therapy visits. After 7 weeks remote practice will continue and the focus of in-person therapy sessions will bridge to social recovery therapy as detailed below.

Component 2: Social recovery therapy (SRT) focuses on addressing barriers to individuals interacting in their social environment e.g., social anxiety. It is informed by cognitive behavioural theory and addresses individual goals. SRT follows an established protocol. In summary, this consists of therapy delivered in three stages. Stage one will include engagement and formulation with the purpose of identifying a problem list and establishing a therapeutic relationship. Stage two will include preparing for new activities with identification of pathways to activity and collaboration with community stakeholders. Stage three will include engagement in new activities using behavioural experiments to promote social activity. This is the primary focus of in-person therapy sessions from week 8 to 15 alongside remote practice of the CRT programme.

Connect with a study center

  • HSE Early Intervention in Psychosis Service, Cork

    Cork,
    Ireland

    Active - Recruiting

  • DETECT Early Intervention in Psychosis Service

    Dublin,
    Ireland

    Active - Recruiting

  • Adult Mental Health Service, University Hospital Galway

    Galway,
    Ireland

    Active - Recruiting

  • HSE Early Intervention in Psychosis Service, Meath

    Meath,
    Ireland

    Site Not Available

  • HSE Early Intervention in Psychosis Service, Meath

    Navan,
    Ireland

    Active - Recruiting

  • HSE Early Intervention in Psychosis Service, Sligo

    Sligo,
    Ireland

    Active - Recruiting

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