Effectiveness of Micro Connective Tissue Graft for Treatment of Multiple Adjacent Gingival Recession Defects

Last updated: March 11, 2025
Sponsor: Göteborg University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Periodontitis

Treatment

Division of the Connective Tissue Graft into multiple micro Connective Tissue Grafts

Coronally Advanced Flap combined with micro Connective Tissue Graft

Modified Coronally Advanced Tunnel combined with a Connective Tissue Graft

Clinical Study ID

NCT06030947
OCarcuac-microCTG
  • Ages 18-60
  • All Genders

Study Summary

The objective of this project is to evaluate 1-year outcomes of treatment of MAGRD using a modified coronally advanced tunnel technique (MCAT) with either conventional CTG (control group) or micro-CTG (test group).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age ≥18 years,

  • systemically healthy,

  • presenting with a minimum of 4 and a maximum of 6 adjacent RT1/RT2 recessions,located in the maxilla or mandible with an apico-coronal extension (i.e. recessiondepth) of ≥2 mm,

  • Full-Mouth Plaque Score (FMPS) <20%,

  • Full-Mouth Bleeding Score (FMBS) <20%.

Exclusion

Exclusion Criteria:

  • pregnancy or lactation,

  • tobacco smoking,

  • uncontrolled medical condition,

  • medication that can affect gingival conditions.

  • thick phenotype,

  • severe tooth malpositioning,

  • uncorrected trauma from toothbrushing,

  • a previous history of root coverage procedures

  • the presence of furcation defects.

Study Design

Total Participants: 30
Treatment Group(s): 7
Primary Treatment: Division of the Connective Tissue Graft into multiple micro Connective Tissue Grafts
Phase:
Study Start date:
March 01, 2025
Estimated Completion Date:
August 01, 2026

Study Description

Gingival recession defects (GRD) present as a partial exposure of the root surface resulting from gingival margin displacement apical to the cemento-enamel junction (CEJ). A variety of surgical methods have been reported to reestablish root coverage, including tunneling techniques and coronally and laterally advanced flaps. As the presence of thin gingival tissues is one of the predisposing factors for GRD, the adjuvant use of subepithelial connective tissue grafts (CTGs) during the surgical correction is often considered. CTGs are thought to contribute to phenotype modification and stability of treatment outcomes and studies have indicated favorable esthetic results and high degrees of root coverage (documented range: 69% to 97%). The procedure does, however, require a suitable donor site. When multiple adjacent teeth exhibit GRDs, the preferred surgical approach should offer the greatest possible root coverage, while limiting drawbacks (i.e., patient morbidity, esthetic problems). Thus, one of the challenges related to coverage of multiple GRDs is the scarcity of donor tissue. In cases when large CTGs are required, additional surgical procedures may even be necessary. As an alternative, a modification of the harvested CTG into multiple "micro-CTGs" is proposed for the treatment of multiple adjacent GRDs (MAGRD). In the present study, the effectiveness and predictability of micro-CTGs will be evaluated in direct comparison to conventional CTGs.

The investigators hypothesise that no statistically significant differences will be observed in terms of % root coverage (primary outcome) and patient satisfaction at 12 months (non-inferiority).

The investigators hypothesise that subjects in the test group (micro-CTG) will report significantly lower morbidity at 1 and 2 weeks post-surgery when compared to controls (superiority).

Connect with a study center

  • Confident Dubai Palm

    Dubai, 0000
    United Arab Emirates

    Active - Recruiting

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