Influence of Overground Walking on Biomarkers, Cognitive Function, and Quality of Life in Elderly With Mild Cognitive Impairment

Last updated: November 5, 2023
Sponsor: Universitas Padjadjaran
Overall Status: Completed

Phase

N/A

Condition

Aging

Dementia

Mild Cognitive Impairment

Treatment

Overground Walking

Clinical Study ID

NCT06029920
IKFR.2023.08.01
  • Ages 60-85
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this research is to investigate the impact of overground walking as a part of a rehabilitation program on the increase in Brain-derived neurotrophic factor (BDNF) levels, decrease in IL-6 levels, decrease in hs-CRP levels, improvement in cognitive function, and enhancement of quality of life (QOL) in older people with mild cognitive impairment. These findings are anticipated to contribute to the efforts to elevate BDNF levels, cognitive function, and QOL while reducing IL-6 and hsCRP levels in the elderly with mild cognitive impairment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Mild cognitive impairment (MoCA INA Score 19-25 out of 30
  • Barthel Index Score 20
  • Geriatric Depression Scale Score ≤ 5
  • Timed Up and Go Test < 15 seconds)
  • Capable of comprehending verbal and written instructions
  • Capable of walking unassisted

Exclusion

Exclusion Criteria:

  • The presence of hearing impairment that could hinder the subject from receiving verbalinstructions,
  • The presence of uncorrected visual impairment
  • Having musculoskeletal disorders
  • Receiving other rehabilitation programs,
  • Presence of diseases causing cognitive impairment
  • Severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsenduring exercise or could pose difficulties in carrying out the exercise program,
  • Severe cardiovascular diseases as diagnosed by a Cardiologist

Study Design

Total Participants: 15
Treatment Group(s): 1
Primary Treatment: Overground Walking
Phase:
Study Start date:
September 05, 2023
Estimated Completion Date:
October 31, 2023

Study Description

This research employs a quasi-experimental research design using a Pretest-Posttest Design approach. The Pretest-Posttest method is executed by assessing before and after the intervention within the same group.

All research subjects receive the same treatment, which involves participating in an overground walking program on a flat surface. The selected research subjects are provided with an explanation of the research's objectives and benefits and the exercise and examination procedures, then sign the informed consent.

Research subjects are instructed to walk on a flat surface for a distance of 15 meters, with a duration of 20 minutes, increasing by 5 minutes each week until the target heart rate is achieved during the exercise. After an 8-week post-intervention period, research subjects will undergo a follow-up examination.

Connect with a study center

  • Nursing Home

    Bandung, Jawa Barat
    Indonesia

    Site Not Available

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