A Study to Evaluate the Nipocalimab and Certolizumab Combination Therapy in Participants With Active Rheumatoid Arthritis

Inclusion Criteria:

• Diagnosis of rheumatoid arthritis (RA) and meeting the 2010 American college ofrheumatology (ACR) or European League Against Rheumatism (EULAR) criteria for RA forat least 3 months before screening

• Has moderate to severe active RA as defined by persistent disease activity with atleast 6 of 66 swollen joints and 6 of 68 tender joints at the time of screening andat baseline

• Is positive for anti-citrullinated protein antibodies (ACPA) or rheumatoid factor (RF) by the central laboratory at the time of screening

• Has C-reactive protein (CRP) greater than or equal to (>=) 0.3 milligram perdeciliter (mg/dL) by the central laboratory at the time of screening

• If has received prior biological disease-modifying antirheumatic drugs (bDMARDs) (orbiosimilars) other than anti-tumor necrosis factor (anti-TNF) agent in RA, hasdemonstrated inadequate response (IR) or intolerance to the therapy based on one ofthe following:

1. IR to at least 1bDMARD (or the biosimilars) other than anti-TNF agents, asassessed by the treating physician, after at least 12 weeks of therapyincluding but not limited to abatacept, anakinra, tocilizumab, and sarilumab orat least 16 weeks of therapy with rituximab Documented IR may includeinadequate improvement or loss in response after initial improvement in jointcounts or other parameters of disease activity

2. Intolerance to bDMARD (or biosimilars) other than anti-TNF agent, as assessedby the treating physician. Documented intolerance includes side effects andinjection or infusion reactions

• If has received prior anti-TNF agent (including biosimilars), has demonstrated IR to >=1 anti-TNF agent (including biosimilars), as assessed by the treating physician:

1. After at least 12 weeks dosage of etanercept, adalimumab, golimumab (includingbiosimilars), and/or

2. After at least 14 weeks dosage (example, at least 4 doses) of infliximab (including biosimilars) Documented IR may include inadequate improvement orloss in response after initial improvement in joint counts or other parametersof disease activity

Exclusion Criteria:

• Has a confirmed or suspected clinical immunodeficiency syndrome not related totreatment of RA or has a family history of congenital or hereditary immunodeficiencyunless confirmed absent

• Is (anatomically or functionally) asplenic

• Has experienced myocardial infarction, unstable ischemic heart disease, or strokeless than or equal to (<=) 12 weeks of screening

• Has a diagnosis of congestive heart failure including medically controlled,asymptomatic congestive heart failure

• Has a history of known demyelinating disease such as multiple sclerosis or opticneuritis