DRP-104 (Glutamine Antagonist) in Combination With Durvalumab in Patients With Advanced Stage Fibrolamellar Carcinoma (FLC)

Inclusion Criteria:

• Must have histologically confirmed FLC (Fibrolamellar Carcinoma) that is metastaticor unresectable.

• Presence of DNAJB1-PRKACA fusion transcript, assessed by RNA-sequencing,DNA-sequencing, or in situ hybridization in the archival tissue.

• Must have demonstrated radiographic progression on prior or current immunotherapy.

• Age ≥ 12 years.

• Patients < 18 years old must have a body weight ≥ 40 kg.

• Eastern Cooperative Oncology Group (ECOG) performance status of ≤2

• Patients must have adequate organ and marrow function defined by study-specifiedlaboratory tests.

• Patients must have adequate kidney and liver function defined by study-specifiedlaboratory tests.

• Must have measurable disease per RECIST 1.1

• Willingness to provide tissue and blood samples for mandatory translationalresearch.

• Women of childbearing potential (WOCBP) must have a negative urine or serumpregnancy test.

• For both Women and Men, must use acceptable form of birth control while on study.

• Ability to understand and willingness to sign a written informed consent document.

Exclusion Criteria:

• Must have had chemotherapy or other systemic therapy or radiotherapy, as follows:

• Patients who have had chemotherapy, biological cancer therapy, or radiation 21days prior to the first dose of study drug.

• Patients who have had surgery within 28 days of dosing of investigationalagent, excluding minor procedures.

• Patients who have received other approved or investigational agents or devicewithin 21 days of the first dose of study drug.

• Patients who have not recovered from acute adverse events to grade ≤1 or baselinedue to agents administered, with exception of grade 2 fatigue, rash, andendocrinopathy successfully managed hormone replacement therapy, or alopecia orstable neuropathy, unless approved by the investigational new drug (IND) Sponsor.

• Patients with corrected QT interval (QTc) prolongation > 470 ms according toFridericia formula.

• Patients receiving potent inducers of Cytochrome P450 3A (CYP 3A4/5) (includingapalutamide, carbamazepine, enzalutamide, mitotane, phenytoin, rifampin and St.John's Wort) that cannot be discontinued at least 14 days prior to Cycle 1 Day 1.

• Known sensitivity to or history of allergic reactions attributed to compounds ofsimilar chemical or biologic composition of DRP-104 or durvalumab.

• Subjects with interstitial lung disease that is symptomatic or may interfere withthe detection or management of suspected drug-related pulmonary toxicity.

• Has a pulse oximetry of <92% on room air or is on supplemental home oxygen.

• Active or untreated brain metastases or leptomeningeal metastases.

• Uncontrolled intercurrent active medical and/or psychiatric illness/socialpsychosocial problems that that would limit compliance with study requirements.

• Uncontrolled intercurrent illness including, but not limited to, uncontrolledinfection, symptomatic congestive heart failure, unstable angina, cardiacarrhythmia, metastatic cancer, or psychiatric illness/social situations that wouldlimit compliance with study requirements.

• Pregnant or breastfeeding.

• Has a known history of Human Immunodeficiency Virus (HIV)/AIDS.

• Has active hepatitis B. Patients with chronic or acute hepatitis B virus (HBV)infection .

• Have had evidence of active or acute diverticulitis, intra-abdominal abscess, or GIobstruction which are known risk factors for bowel perforation should be evaluatedfor the potential need for additional treatment before coming on study.

• Patient is unwilling or unable to follow the study schedule for any reason.

• Patient is at the time of signing informed consent a regular user (including "recreational use") of any illicit drugs or had a recent history (within the lastyear) of substance abuse (including alcohol).

• Evidence of clinical ascites.

• Participants a with history of prior unacceptable and/or life-threatening toxicitiesattributed to anti-programmed death-receptor 1 (PD1) or anti-PD-L1 (anti-programmeddeath-receptor 1) therapy.

• Has active autoimmune disease that has required systemic treatment in the past 2years.

• Prior allogeneic stem cell transplantation or organ transplantation.

• Has a diagnosis of immunodeficiency.

• Systemic corticosteroids at immunosuppressive doses.

• Patients who have had either of the following procedures or medications within 4weeks prior to initiation of study treatment:

• Any live, attenuated vaccine

• Allergen hypo sensitization therapy in the last 2 weeks