Gluten-free Diet in PSC and IBD

Inclusion Criteria (for PSC group):

• Established diagnosis of PSC (based on radiologic features, typical finding on MRCP or ERCP)

• Age 18 - 65 years

• ALP 1,5x higher than ULN

• Signed informed consent

Exclusion Criteria (for PSC group):

• Patients on gluten-free diet

• Patients with coeliac disease or wheat allergy

• Liver transplant recipients

• PSC/AIH overlap syndrome

• Other causes of liver disease

• Radiologic or clinical signs of decompensated liver cirrhosis

• Advanced liver cirrhosis (MELD score ˃ 15)

• Recurrent acute cholangitis or cholangiogenic sepsis in past 3 months

• Use of antibiotics in past 3 months

• History of malignancy

• Pregnant women

• Not signed informed consent

Inclusion criteria (for UC group):

• Ulcerative colitis diagnosed based on clinical, endoscopic and histological findings

• Extension of affected colon > 15cm

• Mayo score 0-4

• Signed informed consent

Exclusion criteria (for UC group):

• CMV, Clostridium difficile enterocolitis in past 3 months

• Use of antibiotics in past 3 months

• Patients with coeliac disease or wheat allergy

• Patients on gluten-free diet

• Pregnant women

• Not signed informed consent

• Biologic therapy

• Methotrexate

• Prednison > 10 mg

• Not signed informed consent