A Study to Evaluate Long-term Safety of Ecopipam Tablets in Children, Adolescents and Adults With Tourette's Disorder

Inclusion Criteria:

• >=6 to >=18 years of age.

• Participants enrolling from the study EBS-101-TD-301; completed all visits throughWeek 24 and days 7 and 14 safety follow-up, met relapse criteria during thedouble-blind randomized (R/WD) period after completing the 301 end of trial (ET)visit, the 7 day and 14 day safety follow up visits, but not before 24 weeksfollowing the 301 baseline visit or participants who met relapse criteria will beeligible after completing early termination visit, Day 7 and Day 14 follow upvisits.

• Participants who completed the studies EBS-101-OL-001 or PSY302A.

• The enrolling participant must have had clinical benefit from ecopipam and wouldbenefit from continued participation.

• Effective contraception during the study and 30 days after last study dose forsexually active participants

• <18 years of age participants parent/legal guardian must sign a written informedconsent and participant must sign a written informed assent.

• Participant must have TD based on Diagnostic and Statistical Manual for MentalDisorders - 5th Edition (DSM-5-TR diagnostic criteria) for TD.

• TD diagnosis and both motor and vocal tics that cause impairment with normalroutines

Exclusion Criteria:

• The participants who discontinued the studies PSY-302A, EBS-101-OL-001 orEBS-101-TD-301 due to reasons such as either lost to follow up, withdrawn consent,non-compliant or withdrawn by the discretion of either the site investigator or thesponsor.

• Participants with ongoing or past history of neurological condition (example [e.g.],Huntington's disease, Parkinson's disease, Wilson's disease, stroke, Restless LegsSyndrome).

• Any unstable mood disorder (DSM-5-TR criteria), mental illness or clinicallysignificant lab abnormalities, moderate to severe renal or hepatic impairment, aPHQ-9 score >=10 at screening and history of neuroleptic malignant syndrome at thetime of screening or baseline.

• Participants who completed the studies EBS-101-OL-001 or PSY-302A and who hadprevious exposure to ecopipam and oral neuroleptics within 4 weeks and depotneuroleptics within 3 months prior to screening, 6 months prior to Baseline.

• Participants receiving any other medication to treat motor or vocal tics andanti-depressant or anti-anxiety medications.

• Risk of suicide as per PI judgement

• Pregnant or lactating women

• Certain medications that would have unfavorable drug interactions with ecopipam,e.g., digoxin, fluoxetine, valproic acid, bupropion.

• Current or recent (past 3 months) DSM-5-TR substance use disorder (with theexception of nicotine).

• Recent behavioral therapy

• Positive urine drug screen for cocaine, amphetamine, benzodiazepines, barbiturates,phencyclidine (PCP) or opiates at Baseline, except those receiving stable,prescribed treatment for attention deficit/hyperactivity disorder (ADHD)

• Lifetime history of bipolar disorder type I or II, dementia, schizophrenia, or anyother psychotic disorder.

• Unable to swallow tablets.

• Known hypersensitivity to any of ecopipam's excipients.

• History of seizures (excluding febrile seizures that occurred >2 years prior toBaseline).

• Myocardial infarction within 6 months from Screening.