A Study to Evaluate the Efficacy and Safety of TL118 in Solid Tumors Patients

Inclusion Criteria:

1. Age 18 years old and above, male or female

2. Histologically or cytologically confirmed diagnosis of locally advanced ormetastatic solid tumor that harbors an NTRK1/2/3 gene fusion that is predicted totranslate into a fusion protein with a functional tropomyosin receptor kinase (TRK)A/B/C kinase domain, without a concomitant second onco-driver

3. Patients must have had disease progression during or after prior treatment for theirtumor, or would be unlikely to tolerate or derive clinical benefit from appropriatestandard of care therapy or are not suitable - in the opinion of the Investigator -to receive standard of care therapy; prior treatment with approved orinvestigational TRK inhibitors is not allowed, except for prior TRK treatment forless than 28 days due to intolerable toxicity)

4. At least one measurable lesion

5. Eastern Cooperative Oncology Group (ECOG) score of 0, 1, or 2

6. A minimum life expectancy of > 3 months

7. Adequate bone marrow reserve, hepatic, renal, and coagulation function

Other inclusion criteria apply for participating in the Study

Exclusion Criteria:

1. Any systemic anti-tumor therapy such as chemotherapy and radiation therapy (including curative radiotherapy or spinal radiotherapy portion > 30%) used within 3weeks prior to enrollment; immunotherapy within 4 weeks; any palliative radiotherapyfor non-target lesions used to relieve symptoms and traditional Chinese medicines (TCMs) indicated for the tumor (including Chinese patent medicine) within 2 weeksprior to enrollment

2. Participation in another interventional clinical trial 2 weeks prior to enrollmentor within 5 half-lives from the last dose of IP (whichever is shorter)

3. Any unresolved toxicities from prior therapy greater than Grade 1, at the time ofscreening with the exception of toxicities posing no safety risk in the opinion ofthe Investigator

4. Active central nervous system metastases

5. Any other primary malignant tumors within 3 years (except for cured skin basal cellcarcinoma and carcinoma in situ of cervix, low-risk cancer

6. Any active infection which has not been controlled at screening

Other exclusion criteria apply for participating in the Study