A Study Comparing Mindfulness Apps to Decrease Anxiety in People With Lung Cancer

Inclusion Criteria:

• Histologically proven lung cancer

• Patients with suspected primary lung cancer per recent chest CT scan (with orwithout contrast) may be enrolled in the trial. These patients may berandomized and begin study intervention without a biopsy. If a patientundergoes a biopsy after consent and the results are negative or if the patientdoes not proceed with surgery, the patient will be removed from the study. Thepatient will continue to receive full access to the AmDTx app for 2-years.

• Scheduled for surgery with at least 14 days lead time (to allow the participantto start the mindfulness practice [intervention group] 14 days preoperatively)

• Age ≥18 years of age at time of signing informed consent

• Access to a smartphone/tablet with data connection

• Willing to give time for mindfulness practice (Patients need to have the motivationto devote approximately 20 to 30 min daily, which is equal to 5 to 7 sessions a weekover the course of a minimum of 6 weeks to do the mindfulness meditations andpractices)

• Willing to be randomized to mindfulness MBCR or CI group and complete allassessments

• High distress level (Distress Thermometer score ≥4 at initial visit)

• Able to understand the study objectives and procedures, comply with the protocol,and sign an informed consent

• Able to read, speak, and understand English

Exclusion Criteria:

• Currently engaging in app-based mindfulness or meditation for one or more times perweek

• As per self-report or as documented in the medical record, current untreated (e.g.,no medication, no therapy) major psychotic disorder (schizotypal personalitydisorder, schizophreniform disorder, schizoaffective disorder). Patients diagnosedwith a major psychiatric disorder will be reviewed by the study PI to determineeligibility before consent

• Individuals with impaired decision-making capacity

• Patients that need to undergo neoadjuvant therapy (chemotherapy±radiation)

• Patients undergoing active treatment of other non-lung cancers

• Patients with recurrent lung cancer