Phase
Condition
Sepsis And Septicemia
Low Blood Pressure (Hypotension)
Treatment
Methylene Blue high dose
Normal saline
Methylene Blue low dose
Clinical Study ID
Ages 18-65 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
- Patients aged ≥ 18 years and ≤ 65 with septic shock as defined by Sepsis-3 criteria (confirmed infection, requiring vasopressor to maintain a mean arterial bloodpressure (MAP) ≥ 65 mmHg, and serum lactate > 2 mmol/L after adequate fluidresuscitation), and requiring mechanical ventilation.
Exclusion
Exclusion Criteria:
myocardial infarction or cerebrovascular accident within the last 3 months.
severe lung , liver or kidney disease (creatinine >3.5 mg/dL).
pregnancy.
glucose 6-phosphate-dehydrogenase deficiency.
known allergy to MB or food dyes and the use of nitrates within the last 3 days.
more than 24 hrs since initiation of norepinephrine.
other causes of shock than sepsis .
recent intake (4-weeks) of selective serotonin re-uptake inhibitors or MAOi.
refusal of the patient guardian to participate.
Study Design
Study Description
Connect with a study center
National Cancer Institute
Cairo, 12588
EgyptSite Not Available
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