Phase
Condition
Holoprosencephaly
Heart Defect
Arrhythmia
Treatment
Placebo
CRD-4730
Clinical Study ID
Ages 18-99 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Males or Females ≥18 years of age, at screening.
Confirmed CPVT diagnosis, based on genetic screening for a known RyR2 mutation and aclinical phenotype consistent with CPVT at screening.
The participant can perform an EST during which frequent premature ventricularcontraction (PVCs) (≥10 per minute), ventricular bigeminy, or higher-grade VA (equivalent to a VA score ≥2) are identified by the investigator.
Stable doses of any anti-arrhythmic medication, except amiodarone, for 4 weeks priorto screening.
Adhere to all contraceptive criteria.
Exclusion
Exclusion Criteria:
Clinically significant structural heart disease, diagnosis of heart failure, orclinically significant coronary artery disease.
History of a myocardial infarction, cerebrovascular accident, or transient ischemicattack within 3 months of screening.
History of malignancy within the past 5 years at screening (except successfullytreated basal cell carcinoma or non-metastatic squamous cell carcinoma of the skinor cervical carcinoma in situ).
Female participant that is pregnant or lactating/ breastfeeding, or has plans to doso during the study or within 3 months following last dose of study drug.
Use of amiodarone with 3 months prior to screening. NOTE: other protocol definedInclusion/ Exclusion criteria may apply.
Study Design
Connect with a study center
Cardurion Investigative Site
Edmonton, Alberta T6G 2R7
CanadaSite Not Available
Stollery Children's Hospital University of Alberta
Edmonton, Alberta T6G 2R7
CanadaActive - Recruiting
British Columbia Children's Hospital
Vancouver, British Columbia V6H 3N1
CanadaActive - Recruiting
Cardurion Investigative Site
Vancouver, British Columbia V6Z1Y6
CanadaSite Not Available
University of British Columbia (UBC) Hospital
Vancouver, British Columbia V5Z 1M9
CanadaActive - Recruiting
Cardurion Investigative Site
London, Ontario N6A 5A5
CanadaSite Not Available
University of Western Ontario
London, Ontario N6A 5A5
CanadaActive - Recruiting
Cardurion Investigative Site
Nantes, Loire-Atlantique 44805
FranceSite Not Available
Hôptal Nord Laennec
Nantes, Loire-Atlantique 44805
FranceActive - Recruiting
Cardurion Investigative Site
Bron, 69677
FranceSite Not Available
Hôpital Louis Pradel
Bron, 69677
FranceActive - Recruiting
Cardurion Investigative Site
Paris, 75018
FranceSite Not Available
Groupe Hospitalier Bichat Claude Bernard
Paris, 75018
FranceActive - Recruiting
Cardurion Investigative Site
Saint-Herblain, 44800
FranceSite Not Available
Cardurion Investigative Site
Pavia, Lombardia 27100
ItalySite Not Available
IRCCS Pavia Istituti Clinici Scientifici Maugeri Spa Società Benefit
Pavia, Lombardia 27100
ItalyActive - Recruiting
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229
United StatesActive - Recruiting
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229
United StatesSite Not Available
Cardurion Investigative Site
Cleveland, Ohio 44195
United StatesSite Not Available
Cleveland Clinic Children's Hospital
Cleveland, Ohio 44195
United StatesActive - Recruiting
Baylor College of Medicine
Houston, Texas 77030
United StatesActive - Recruiting
Cardurion Investigative Site
Houston, Texas 77030
United StatesSite Not Available
Not the study for you?
Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.