Complementary and Integrative Medicine as an Online Intervention in Patients With Post-covid Syndrome After COVID-19

Inclusion criteria:

• Acute SARS-CoV2 infection at least 12 weeks ago (documented by PCR test results orSARS-CoV-2 antibodies)
• History of chronic fatigue (after SARS-CoV-2 infection)
• At least 3 of 7 criteria fulfilled at the time of inclusion: sleep disturbance,headache, joint pain/muscle pain, anxiety/depression, memory impairment/concentrationdisturbance, postexertional malaise, dysosmia/anosmia
• Numerical Rating Scale (NRS, 0-10 points, 0 = not able to exercise at all; 10 = fullexercise capacity) physical exercise capacity of max. 6 points ("What is your physicalexercise capacity on average over the last 7 days?")
• Short Form-36 Physical Function Subscale (SF-36 PFS) of maximum 65 points
• Patient are technically equipped enough to participate in the online intervention andwilling to follow the study procedure to perform the online intervention at home

Exclusion criteria:

• Fatigue already present before SARS-CoV-2 infection
• Presence of severe post-exertional malaise (PEM) (according to DSQ-PEM tool question 7OR 8 with yes AND >14h condition worsening)
• Other underlying conditions leading to symptoms of chronic fatigue, such as unstablemental illness, oncological disease(s), MS, fibromyalgia, and substance abuse
• Other serious underlying medical conditions, such as severe pulmonary, cardiac,psychiatric, or infectious diseases that could interfere with study participation oraffect results • Ongoing opioid therapy or opioid therapy in the week prior to studyentry
• Regular use of cannabinoids or other illicit drugs in the month prior to or during thestudy
• Restarting or discontinuing psychotherapy during study participation in the 6 weeksprior to study entry
• Pregnancy or breastfeeding
• Participation in another clinical intervention study during study participation 1
• Regular use of Complementary and Integrative Medicine self-help measures (e.g.meditation, Kneipp hydrotherapiy, etc.) within the study period
• Current pension procedure or planned claiming of a pension procedure due to disability
• Planned rehabilitation measures during study participation due to post-COVID syndrome Inclusion and exclusion criteria of the sub-study focus group interviews with physicians Inclusion criteria:
• Family physicians and general practitioners
• Regular outpatient care of patients with post-covid syndrome
• Willingness in principle to participate in a 2-hour interview on-site or online Exclusion criteria:

• No previous care of post-covid patients