Safety, Tolerability, and Efficacy of Enteral Nutrition Versus Standard of Care Nutrition in Hematopoietic Stem Cell Transplant Patients: A Pilot Study

Inclusion Criteria:

1. Have plans to be admitted or be admitted to an inpatient pediatric or adult ward forthe purpose of HSCT.

2. Be greater than 2 years of age and less than 25 years of age at time of studyenrollment.

3. Participants > 18 or guardians for participants < 18 are willing and able to givewritten informed consent and to comply with all of the study activities. Assent isrequired for children > 7 years old. a) Participants must be English, Italian, Chinese/Mandarin, or Spanish speaking

4. Participants will be encouraged to co-enroll on two additional related energy -balance protocols (highly encouraged but not required)

5. MDACC protocol PA18-0130. This protocol will enable us to track physicalactivity through their receipt of a Fitbit (Pediatric Energy Balance DataRepository Protocol.) , and

6. MDACC protocol LAB99-062 "A Study to Collect Peripheral Blood, Tissue, and BoneMarrow samples from Donors and Recipients of blood and marrow transplants forLaboratory Research" which will allow collection of stool for exploration ofthe effects of feeding on microbiome data specifically.

7. Participants will be asked to consider co-enrollment on Stem Cell Registry study (not required):

8. PA19-0756: This is a prospective multi-center study to understand thecontribution of vascular endothelial dysfunction towards morbidity andmortality among children and adolescents/young adults (AYA) undergoing HCT/CT.

Exclusion Criteria:

1. Patients in whom EN is contraindicated (e.g intestinal ischemia, complete bowelobstruction, or other anatomical obstructive process), or all available routes of ENare contraindicated. Surgical GT placements for the sole purpose of studyparticipation will not be entertained. See Table 1

2. Females who are pregnant. We follow FACT guidelines. Per Foundation for theAccreditation of Cellular Therapy (FACT), female patients must have a negativepregnancy test 7 days prior to bone marrow transplant.