Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics

Last updated: July 10, 2024
Sponsor: First Affiliated Hospital Xi'an Jiaotong University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dermatomyositis (Connective Tissue Disease)

Coronary Artery Disease

Thrombosis

Treatment

Observational; No Interventions were given.

Clinical Study ID

NCT06001073
XJTU1AF2023LSK-353
  • Ages 3-80
  • All Genders

Study Summary

The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear. Improving diagnosis and treatment, clarifying the pathogenesis, and providing scientific basis for the prevention and treatment are hot research topics in the study of cardiovascular and cerebrovascular diseases. This study intends to collect clinical data and biological specimen data of patients with cardiovascular and cerebrovascular diseases who meet the inclusion and exclusion criteria, and use multi-omics technology to deeply understand the pathogenic mechanisms of cardiovascular and cerebrovascular diseases and provide new ideas for specific and individualized treatment of patients with cardiovascular and cerebrovascular diseases, to construct early predictive prognostic models and provide a basis for effective treatment of clinical practice in patients with cardiovascular and cerebrovascular diseases.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients who are regularly visited and followed up in the appropriate patient;department.

  • All patients met at least one of the following diagnostic criteria forcardiovascular and cerebrovascular diseases:

  • coronary artery disease group;

  • arrhythmia group;

  • heart valve disease group;

  • aortic dissection group;

  • cardiac masses group;

  • myocarditis group;

  • hypertension group;

  • cardiomyopathy group;

  • structural heart disease group;

  • ischemic cerebrovascular disease group;

  • hemorrhagic cerebrovascular disease group;

  • intracranial space occupying lesion group.

Exclusion

Exclusion Criteria:

  • Age <3 years or >80 years old;

  • Pregnant and lactating women;

  • The patient declined to provide informed consent to participate in the study;

  • None of the above was met, but the patient was temporarily unable to sign theinformed consent form due to coma and other reasons, and no legal representativesigned it instead. Depending on the patient's condition, the patient may not be ableto regain consciousness and sign the informed consent form.

Study Design

Total Participants: 25000
Treatment Group(s): 1
Primary Treatment: Observational; No Interventions were given.
Phase:
Study Start date:
December 05, 2022
Estimated Completion Date:
December 31, 2028

Study Description

Cardiovascular and cerebrovascular diseases refer to ischemic and hemorrhagic diseases of the heart, brain and body tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, hypertension, etc. It is one of the major public health problems in the world. The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear. Improving diagnosis and treatment, clarifying the pathogenesis, and providing scientific basis for the prevention and treatment are hot research topics in the study of cardiovascular and cerebrovascular diseases. This study intends to collect clinical data and biological specimen data of patients with cardiovascular and cerebrovascular diseases who meet the inclusion and exclusion criteria, and use multi-omics technology to deeply understand the pathogenic mechanisms of cardiovascular and cerebrovascular diseases and provide new ideas for specific and individualized treatment of patients with cardiovascular and cerebrovascular diseases, to construct early predictive prognostic models and provide a basis for effective treatment of clinical practice in patients with cardiovascular and cerebrovascular diseases.

Connect with a study center

  • First Affiliated Hospital of Xian Jiantong University

    Xi'an, Shaanxi 710061
    China

    Active - Recruiting

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