Background: People with diabetes and either current or previous diabetic foot ulcer disease
(DFUD) are at very high risk for adverse cardiovascular events including heart attacks and
strokes. Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a class of medications that
have shown to be very effective in reducing heart disease and event risk. However, one recent
study found that SGLT2i's may increase minor amputation risk in those with DFUD, though this
finding has not been replicated in other similar studies. However, as a result, there has
been limited further investigation into this issue and as such the use of SGLT2i's in those
with DFUD remains a contentious issue, despite their potential for significantly reducing
cardiovascular disease risk in this population.
In the absence of further randomised controlled trials investigating the use of SGLT2is in
these populations, there is a need for clinical guidelines advising on their use based on
expert clinical consensus, including specific criteria or scenarios in which they should or
should not be used. The Delphi methodology is an iterative survey technique that uses expert
opinion from various relevant backgrounds and experiences to generate a consensus based upon
various statements and/or scenarios.
Aim: The aim of this study is to use the Delphi technique to generate expert consensus-based
clinical guidelines on the use of SGLT2i's in those with diabetes and DFUD.
Methods: This is a Delphi technique-based study using a purposive sample of convenience.
Consensus development methods will be used to generate clinical guidelines, endorsed by key
clinical groups, on the use of SGLT2i's in patients with diabetic foot ulcer disease,
including acknowledgement of specific scenarios or patient characteristics that may influence
these guidelines.
The consensus group will consist of n=20 healthcare practitioners, including GPs, secondary
care diabetologists, foot care specialists, cardiologists and pharmacists in order to ensure
a breadth of expertise and input. Two rounds of the Delphi consensus process will take place,
in order to iteratively develop the consensus-based clinical guidelines. This process is
expected to take 4-6 months. The analysis will be on-going throughout the study and completed
within 3 months of the last questionnaire round of the Delphi process.