Transfer of Feces in Ulcerative Colitis 2

Inclusion Criteria:

• Age ≥18 and <70

• Ability to give informed consent

• Established ulcerative colitis with known involvement of the left colon according tothe Lennard-Jones criteria

• Partial mayo score of ≥ 3 and calprotectin > 250

• Full Mayo score 5-9

• Endoscopic Mayo score of ≥2 in either the rectum or sigmoid upon screeningsigmoidoscopy

• Stable dose of thiopurines or , 5-ASA, or budesonide in preceding 8 weeks.

• Stable dose of budesonide in preceding 2 weeks.

• Prednisone use ≤15mg/day in preceding 2 weeks with a mandatory taper of 5 mg perweek starting from week 4.

• Women need to use reliable contraceptives during participation in the study

• Alkaline phosphatase > 1.5 x ULN in the subgroup of PSC/UC patients.

Exclusion Criteria:

• Condition leading to profound immunosuppression

• For example: HIV, infectious diseases leading to immunosuppression, bone marrowmalignancies

• Use of systemic chemotherapy

• Child-Pugh B liver cirrhosis

• Anti-TNFα treatment in preceding 2 months

• Vedolizumab treatment in preceding 2 months

• Tofacitinib treatment in preceding 2 months

• Ustekinumab treatment in preceding 2 months

• Cyclosporine treatment in preceding 4 weeks

• Use of Methotrexate in preceding 2 months

• Prednisolone dose > 15 mg/day in preceding 2 weeks

• Use of topical therapy in preceding 2 weeks

• Life expectancy < 12 months

• Difficulty with swallowing

• Use of systemic antibiotics in preceding 4 weeks

• Use of probiotic treatment in preceding 4 weeks

• Positive stool cultures for common enteric pathogens (Salmonella, Shigella,Yersinia, Campylobacter, enteropathogenic e coli)

• Positive C. Difficile stool test

• Positive dual faeces test for pathogenic parasites e.g. Dientamoeba histolytica,Giardia Lamblia, Dientamoeba fragilis, Blastocystis hominis only if microscopicallymany or very many blastocysts are seen.

• Positive serological test for HIV

• History of surgery:

• presence of a pouch

• presence of stoma

• Known intra-abdominal fistula

• Pregnancy or women who give breastfeeding

• Vasopressive medication, icu stay

• Signs of ileus, diminished passage

• Allergy to macrogol or substituents, eg peanuts, shellfish

• Known allergy to iv gadolinium in the subgroup of patients who would be scheduledfor MRI liver

• Crohn's disease

• Subject who has any conditions that in the opinion of the investigator, wouldcompromise the safety of the subject or the quality of the data and is an unsuitablecandidate for the study