Efficacy of 7-day Versus 14-day Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori（SHARE2302)

Last updated: January 9, 2024
Sponsor: Shandong University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

7days bismuth quadruple

14 days bismuth quadruple

Clinical Study ID

NCT05997433
SHARE2302
  • Ages 18-70
  • All Genders

Study Summary

Helicobacter pylori (H. pylori) infection is a common global infectious disease of the gastrointestinal tract. Helicobacter pylori eradication can effectively prevent the development of gastric cancer.The researchers collect H.pylori-positive patients who need native therapy. The subjects were randomized to receive7 days and 14 days of bismuth quadruple eradication therapy. 6-8 weeks after treatment, the subjects will re-take the 13C-urea breath test. Calculate the eradication rates, adverse reaction rates and patient compliance of each group.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients aged 18-70.
  2. Without active hepatitis.
  3. Helicobacter pylori infection (either positive for rapid urease test, C13/C14 ureabreath test).
  4. Patients who have not previously received helicobacter pylori eradication therapy.

Exclusion

Exclusion Criteria:

  1. Patients with serious underlying diseases, such as liver insufficiency (Aspartateaminotransferase or alanine aminotransferase greater than the normal value), renalinsufficiency (Cr≥2.0mg/dL or glomerular filtration rate <50 ml/min),immunosuppression, malignant tumors, Coronary heart disease or coronary arterystenosis ≥75%.
  2. Patients who are pregnant or lactating or unwilling to take contraceptive measuresduring the trial.
  3. Patients with active gastrointestinal bleeding.
  4. Patients with a history of upper gastrointestinal surgery.
  5. Patients allergic to treatment drugs.
  6. Patients with medication history of bismuth agents, antibiotics, proton pump inhibitorand other drugs within 4 weeks.
  7. Patients with other behaviors that may increase the risk of illness, such as alcoholand drug abuse.
  8. Patients who are unwilling or incapable to provide informed consents.

Study Design

Total Participants: 254
Treatment Group(s): 2
Primary Treatment: 7days bismuth quadruple
Phase:
Study Start date:
September 02, 2023
Estimated Completion Date:
August 30, 2024

Study Description

Related studies have shown that 7-day bismuth quadruple therapy is not inferior to 14-day bismuth quadruple therapy in the eradication of clarithromycin-resistant H. pylori.The results of the current study conducted by our team on the eradication of H. pylori in 10-day versus 14-day courses of bismuth quadruple therapy showed that the 10-days (92.09%) was not inferior to the 14-days(92.38%), but the incidence of adverse effects was significantly lower in the 10-day courses than in the 14-days(30.62%). If it can be demonstrated that the eradication rate of the 7-day course of bismuth quadruplex is close to that of the 14-days, then the 7-day course may be chosen.

The researchers collect H.pylori-positive patients who need native therapy. If the subject meets the selection criteria but not the exclusion criteria, and signs an informed consent form, the researchers randomized the subjects in groups: subjects received 7days or 14days bismuth quadruple eradication therapy. The medication of groups are as follows. 6-8 weeks after the eradication treatment, the subjects will review the 13C-urea breath test, and the researcher records the results.

After all subjects were tested, the eradication rates, adverse reaction rates and patient compliance of each group were calculated.

According to therapy, it is randomized into a 7days treatment group and a 14 days treatment group. The two groups of bismuth quadruple regimens are the same, as follows:

7days group: Amoxicillin 1000mg bid+ Tetracycline 500mg qid+ Bismuth + Tegoprazan 50mg bid 14days group: Amoxicillin 1000mg bid+ Tetracycline 500mg qid+ Bismuth + Tegoprazan 50mg bid

Connect with a study center

  • Department of Gastroenterology, Qilu Hospital, Shandong University

    Jinan, Shandong 250012
    China

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.