Phase
Condition
N/ATreatment
low intensity focused ultrasound (LIFU)
Clinical Study ID
Ages 45-85 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Males and non-pregnant females, aged 45-85 years
Able and willing to give informed consent
Must meet the clinical criteria for MCI due to Alzheimer's disease
If receiving concurrent treatment with an AChEI and/or memantine, has been on astable dose for at least 45 days
Able to communicate sensations during the LIFU procedure
Exclusion
Exclusion Criteria:
Unable to undergo MR-imaging because of implanted pacemakers, medication pumps,aneurysm clips, metallic prostheses (including metal pins and rods, heart valves orcochlear implants), shrapnel fragments, permanent make-up or small metal fragmentsin the eye that welders and other metal workers may have, or if candidates areuncomfortable in small spaces (have claustrophobia).
Participants with more than 30% of the skull area traversed by the sonicationpathway are covered by scars, scalp disorders (e.g., eczema), atrophy of the scalp,or implanted objects in the skull or the brain.
Participants with a history of seizure disorder.
Participants with clinically significant chronic pulmonary disorders e.g., severeemphysema, pulmonary vasculitis, or other causes of reduced pulmonary vascularcross-sectional area.
Participant does not speak English
Participant is pregnant or planning to be pregnant
Study Design
Study Description
Connect with a study center
Rockefeller Neuroscience Institute at West Virginia University
Morgantown, West Virginia 26505
United StatesActive - Recruiting
Not the study for you?
Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.