Low-Intensity Focused Ultrasound (LIFU) Neuromodulation

Inclusion Criteria:

• Males and non-pregnant females, aged 45-85 years

• Able and willing to give informed consent

• Must meet the clinical criteria for MCI due to Alzheimer's disease

• If receiving concurrent treatment with an AChEI and/or memantine, has been on astable dose for at least 45 days

• Able to communicate sensations during the LIFU procedure

Exclusion Criteria:

• Unable to undergo MR-imaging because of implanted pacemakers, medication pumps,aneurysm clips, metallic prostheses (including metal pins and rods, heart valves orcochlear implants), shrapnel fragments, permanent make-up or small metal fragmentsin the eye that welders and other metal workers may have, or if candidates areuncomfortable in small spaces (have claustrophobia).

• Participants with more than 30% of the skull area traversed by the sonicationpathway are covered by scars, scalp disorders (e.g., eczema), atrophy of the scalp,or implanted objects in the skull or the brain.

• Participants with a history of seizure disorder.

• Participants with clinically significant chronic pulmonary disorders e.g., severeemphysema, pulmonary vasculitis, or other causes of reduced pulmonary vascularcross-sectional area.

• Participant does not speak English

• Participant is pregnant or planning to be pregnant