A Clinical Study of Theta Burst Stimulation (cTBS) in the Treatment of Insomnia Disorder Targeting the Dentate Nucleus of the Cerebellum

Inclusion Criteria:

• All participants aged from 18 to 60 years old; all participants met diagnosticcriteria for insomnia disorder according to the Diagnostic and Statistical Manual ofMental Disorders-V (DSM-V), and scored >10 on PSQI , ≤14 on the Hamilton AnxietyScale (HAMA), and ≤17 on the Hamilton Depression Scale (HAMD); no sleep-affectingdrugs were taken 1 month before or during the trial (non-prescription sleepmedication, benzodiazepines or hypnotics, ect.); patients can cooperate to completethe treatment and related examination items; all subjects signed informed-consentforms before enrolling in the trial.

Exclusion Criteria:

• The patient is unable to cooperate with the completion of treatment andexaminations; there are other types of sleep disorders; a history of psychotropicdrug or alcohol dependence or abuse in the last 2 years; have undertakentrans-meridian travel across more than two time zones or worked night shifts in thepreceding one month or during the trial period; plan surgical treatment within 1month before or during the trial; evidence of neurological or other physicaldiseases such as respiratory, cardiac, renal, hepatic, endocrinal diseases and otherpsychiatric diseases as assessed by clinical history, physical examination orroutine laboratory tests; pregnancy or breastfeeding women; any contraindication forrTMS (including implanted metal and devices in the body, and history of epilepsy);concurrent other clinical trials; patient or family member withdrawsinformed-consent.