Evaluation of health effects of domestic adlay on lowering cholesterol and blood sugar
Hyperlipidemia and diabetes are major risk factors for cardiovascular disease. Clinical
experiments have preliminarily proved that phytosterols can help lower blood lipids, and
adlay is one of the domestic economic crops that has animal experimental evidence or
theoretical potential to be beneficial to blood lipids and blood sugar control, which needs
to be further explored and verified. This study explores the efficacy of domestic adlay in
improving blood sugar and lipids metabolism, cardiovascular function, and weight control in
people with high blood pressure, hyperlipidemia, and hyperglycemia.
We plan to recruit 60 patients with hyperglycemia or hyperlipidemia. aged between 20 and 80
years old, from National Taiwan University Hospital. This study is focused on high blood
cholesterol, triglycerides, and hyperglycemia groups, thus participants must have higher
cholesterol, triglycerides, or higher fasting blood glucose concentration even under
currently stable treatment for at least 6 months. Lipid-lowering and hypoglycemic medication
cannot be changed during this trial.
The clinical trial adopts a randomized cross-over trial, the experimental group to eat white
rice with adlay and the control group to eat white rice. Participants in the project were
randomly divided into two groups, group A and B, with 30 people in each group. Group A eat
adlay to replace their carbohydrates: a box of 200 grams of rice (the amount of rice in dry
weight is 36 grams of adlay and 54 grams of white rice) per day; Group B ate a box of 200
grams of white rice (the amount of rice was 87 grams based on dry weight) per day. After the
first run of study, all participants resume to the original regular diet for two weeks, and
then switch groups for crossover trial after the two-week washout period. In the experiment,
during the crossover experiment, group A and group B replaced the experimental ingredients,
that is, the original white rice group was replaced by adlay with white rice, and the
original adlay and white rice group was replaced with white rice for a period of two weeks.
To ensure that the test material is homogeneous and uniform, the white rice with adlay is
made from the "cooked rice with adlay" produced by Nanqiao Group, HUACIANG INDUSTRY CO., LTD.
The adlay cooked rice contains 40% adlay and Taichung No. 194 white rice 60%, and the control
group used Taichung No. 194 white rice.
Every participant have to receive blood and urine sampling for biochemical measurement in
each stage, 1. Baseline, 2. Two weeks after first stage: adlay with white rice or white rice,
3. Washed period stage for 2 weeks, 4. Two weeks after crossover stage. The main results
analysis includes fasting blood sugar,glycosylated hemoglobin, glycosylated hemoglobin,
triglycerides, total cholesterol, high-density cholesterol, and low-density cholesterol.
Secondary outcome analysis includes blood pressure, body composition analysis, inflammation
index, thyroid function, levels of intestinal hormones (cholecystokinin, gastrin) and
glucagon-like peptide-1, and other emerging blood lipid indicators, such as small-dense
LDL-C. The above measurements will be performed every 2 weeks for each stage. Pittsburgh
Sleep Quality Index and Center for Epidemiological Studies Depression Scale (CES-D) will also
be assessed every 2 weeks for each stage.
Keywords: hyperlipidemia, hyperglycemia, diabetes mellitus, randomized crossover trial