A Study of Contrast-Enhanced Mammography (CEM) Scans in People With Breast Cancer

Last updated: May 16, 2025
Sponsor: Memorial Sloan Kettering Cancer Center
Overall Status: Trial Not Available

Phase

N/A

Condition

Cancer

Breast Cancer

Treatment

Contrast-Enhanced Mammography

Breast MRI

Clinical Study ID

NCT05990478
23-224
  • Ages > 18
  • Female

Study Summary

The purpose of this study is to find out whether Contrast-Enhanced Mammography/CEM scans performed 2 minutes and 6 minutes after receiving Iohexol contrast dye can be used to identify the amount of residual disease in the breast following neoadjuvant treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Any women >18 years of age at time of informed consent

  • Diagnosed with breast cancer and schedule for NAT

Exclusion

Exclusion Criteria:

  • History of kidney disease, creatinine level >1.3 or eGFR <45.

  • Known allergic reaction to gadolinium or iodinated contrast media.

  • Contraindication to contrast-enhanced breast MRI.

  • Lesion not included in the field of view of either pre- or post-NAT MRI or CEM

  • Presence of pacemakers or automated implantable cardioverter defibrilator

  • Pregnant women

Study Design

Treatment Group(s): 2
Primary Treatment: Contrast-Enhanced Mammography
Phase:
Study Start date:
August 03, 2023
Estimated Completion Date:
July 26, 2024

Connect with a study center

  • Memorial Sloan Kettering at Basking Ridge (All protocol activities)

    Basking Ridge, New Jersey 07920
    United States

    Site Not Available

  • Memorial Sloan Kettering Monmouth (All Protocol Activities)

    Middletown, New Jersey 07748
    United States

    Site Not Available

  • Memorial Sloan Kettering Bergen (All protocol activities)

    Montvale, New Jersey 07645
    United States

    Site Not Available

  • Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities )

    Commack, New York 11725
    United States

    Site Not Available

  • Memorial Sloan Kettering Westchester (All Protocol Activities)

    Harrison, New York 10604
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center (All protocol activites)

    New York, New York 10065
    United States

    Site Not Available

  • Memorial Sloan Kettering Nassau (All protocol activities)

    Rockville Centre, New York 11553
    United States

    Site Not Available

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