Effectiveness and Safety of Topical Finasteride and Minoxidil Combination Compared to Topical Minoxidil for The Treatment of Male Androgenetic Alopecia

Last updated: September 21, 2023
Sponsor: Indonesia University
Overall Status: Active - Recruiting

Phase

2/3

Condition

Male Pattern Baldness

Alopecia

Scalp Disorders

Treatment

Minoxidil

Finasteride

Clinical Study ID

NCT05990400
23030293
  • Ages 18-59
  • Male
  • Accepts Healthy Volunteers

Study Summary

A double-blind, randomized, controlled trial of 40 male patients with androgenetic alopecia was conducted. All subject were randomized to receive either combination of minoxidil 5% topical and finasteride 0,1% topical or minoxidil 5% topical

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Male aged from 18-59 years diagnosed with androgenic alopecia
  2. Androgenic alopecia type III-V according to Hamilton-Norwood criteria
  3. Willing to participate in this research by signing the consent form after receiving anexplanation from the researcher
  4. Willing to not cutting the hair nor coloring the hair during the study

Exclusion

Exclusion Criteria:

  1. Diagnosed with other infectious or inflammatory skin disease in the scalp
  2. Using oral medications or vitamins that aim to increase the amount of hair in the last 1 month
  3. Using topical medication that aim to increase the amount of hair in the last 2 weeks
  4. Undergoing cosmetic procedure for AGA therapy such as low-level laser therapy (LLLT)procedures, platelet-rich plasma (PRP) injections, or microneedling within the last 3months
  5. Have sexual disorder such as decreased libido
  6. Have a history of allergy or irritant contact dermatitis to the minoxidil andfinasteride

Study Design

Total Participants: 40
Treatment Group(s): 2
Primary Treatment: Minoxidil
Phase: 2/3
Study Start date:
May 01, 2023
Estimated Completion Date:
December 30, 2023

Study Description

All subject were randomized to receive either combination of minoxidil 5% topical and finasteride 0,1% topical or minoxidil 5% topical The primary outcome was increase of the hair density and hair diameter (mean thickness) measured by trichoscan Measurements were done at baseline and every four weeks for twelve weeks. Additionally, side effects of therapy was also measured.

Connect with a study center

  • University Indonesia

    Jakarta, Other (Non U.s.) 10250
    Indonesia

    Active - Recruiting

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