Phase I Clinical Trial of 68Ga-NOTA-SNA002

Inclusion Criteria:

1. Age 18-75 years old (including boundary values);

2. Those who have behavioral capacity, voluntarily participate in this clinical study,and sign an informed consent form (ICF);

3. Physical condition (ECOG) score 0-2 points;

4. Basal heart rate 60~100 beats/min (including the boundary value, which refers to theseated heart rate of the patient in a calm state);

5. Blood pressure measurements < High blood pressure level 1 (includes a history ofhigh blood pressure, systolic blood pressure treated with exercise or medication; 140 and diastolic blood pressure< 90mmHg); Specialty situation

6. Patients with confirmed solid tumors (including but not limited to non-small celllung cancer, breast cancer, head and neck squamous cell carcinoma, malignantmelanoma) with or without metastatic tumors;

7. Patients whose imaging findings indicate that at least one target lesion ismeasurable and can be biopsied (CT, MRI, or 18F-FDG PET-CT results are acceptable);

8. Pathological findings were obtained within the previous 1 year.

Exclusion Criteria:

1. Patients who are unable to perform visits or undergo relevant examinations,operations or biopsies in accordance with the clinical trial protocol;

2. Poor nutritional status, screening BMI< 18.5, can not tolerate the test;

3. People with known or suspected evidence of active autoimmune disease (e.g.,vitiligo, diabetes, residual hypothyroidism due to autoimmune disease requiringhormone replacement therapy only, autoimmunological disease such as psoriasis thatdoes not require systemic treatment), Or diseases that are not expected to recur inthe absence of external triggers are allowed to be included in the study);

4. Patients who take large doses of hormones, such as hydrocortisone or 5mg prednisonein the morning and hydrocortisone or 2.5mg prednisone in the evening;

5. Patients with serious diseases or other malignant tumors (except those who have beencured one year ago or do not require additional treatment);

6. People with known severe allergy to 68Ga-NOTA-SNA002, similar drugs or excipients.