Intranasal Insulin for Treatment of Alcohol Use Disorder

Inclusion Criteria:

• ≥21 years
• meet any DSM-5 criteria score for AUD
• Individuals who, in the last month, have consumed at least the same amount ofalcohol that will be administered in the laboratory procedure (i.e. to reach BrAClevels of 0.08g/dl, ~two drinks in one occasion)
• BrAC=0.00g/dL at each visit
• good health as confirmed by medical history, physical examination and lab tests
• willing to adhere to the study procedures
• understand informed consent and questionnaires in English at an 8th grade level
• willing to have glucose monitored by finger stick during the laboratoryprocedures

Exclusion Criteria:

• • female identifying who are breastfeeding or pregnant (assessed by a urine screen)
• individuals with diabetes
• history of suicide attempts in the last three years
• current diagnosis of other substance use disorder (other than nicotine orcannabis)
• use of drugs (e.g. stimulants/opioids) at each alcohol administration session (byurine tox screen)
• cannabis intoxication (by clinical assessments)
• use of medications that may interact with insulin and alcohol (by Micromedexdatabase)
• hypersensitivity to insulin
• any nasal disease/congestion that may interfere with intranasal drug absorption;
• baseline hypoglycemia (blood glucose ≤65mg/dL) or hyperglycemia (blood glucose >200mg/dL) (by finger stick)